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Q5PPI4

- LAMP5_RAT

UniProt

Q5PPI4 - LAMP5_RAT

Protein

Lysosome-associated membrane glycoprotein 5

Gene

Lamp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 5
    Alternative name(s):
    Brain and dendritic cell-associated LAMP
    Brain-associated LAMP-like protein
    Short name:
    BAD-LAMP
    Lysosome-associated membrane protein 5
    Short name:
    LAMP-5
    Gene namesi
    Name:Lamp5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1306991. Lamp5.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Endosome membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane By similarity; Single-pass type I membrane protein By similarity. Recycling endosome By similarity
    Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB
    2. dendrite Source: UniProtKB-SubCell
    3. dendrite membrane Source: UniProtKB
    4. early endosome membrane Source: UniProtKB
    5. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
    6. endosome membrane Source: UniProtKB
    7. growth cone membrane Source: UniProtKB
    8. integral component of membrane Source: UniProtKB-KW
    9. plasma membrane Source: UniProtKB
    10. recycling endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000360414Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5PPI4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PPI4.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAMP family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41798.
    GeneTreeiENSGT00390000012584.
    HOGENOMiHOG000231912.
    HOVERGENiHBG051186.
    InParanoidiQ5PPI4.
    OMAiCPVDERE.
    OrthoDBiEOG7DRJ3S.
    PhylomeDBiQ5PPI4.
    TreeFamiTF330776.

    Family and domain databases

    InterProiIPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PROSITEiPS00310. LAMP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5PPI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLRGRALLG GDRLRILLMF FHAMAQTVAE QEVENLSGLS TNPEKDIFVV    50
    RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGRCG 100
    HNESELQVFW VDRAYTLKML FVKESHNTSK GLEATWKLSK VQFVYDSSEK 150
    THFKDAVSAG KHTANSHHLS ALVTPAGMSY ECQAQQTISL ASSDPQKTVT 200
    MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIV 250
    ITLVIYHIHH KMTANQVQIP RDRSQYKHMG 280
    Length:280
    Mass (Da):31,505
    Last modified:January 4, 2005 - v1
    Checksum:i555111CD85C8A8FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473949 Genomic DNA. Translation: EDL80298.1.
    BC087680 mRNA. Translation: AAH87680.1.
    RefSeqiNP_001014205.1. NM_001014183.1.
    UniGeneiRn.13757.

    Genome annotation databases

    EnsembliENSRNOT00000007274; ENSRNOP00000007274; ENSRNOG00000005457.
    GeneIDi362220.
    KEGGirno:362220.
    UCSCiRGD:1306991. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473949 Genomic DNA. Translation: EDL80298.1 .
    BC087680 mRNA. Translation: AAH87680.1 .
    RefSeqi NP_001014205.1. NM_001014183.1.
    UniGenei Rn.13757.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5PPI4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007274 ; ENSRNOP00000007274 ; ENSRNOG00000005457 .
    GeneIDi 362220.
    KEGGi rno:362220.
    UCSCi RGD:1306991. rat.

    Organism-specific databases

    CTDi 24141.
    RGDi 1306991. Lamp5.

    Phylogenomic databases

    eggNOGi NOG41798.
    GeneTreei ENSGT00390000012584.
    HOGENOMi HOG000231912.
    HOVERGENi HBG051186.
    InParanoidi Q5PPI4.
    OMAi CPVDERE.
    OrthoDBi EOG7DRJ3S.
    PhylomeDBi Q5PPI4.
    TreeFami TF330776.

    Miscellaneous databases

    NextBioi 679076.
    PROi Q5PPI4.

    Gene expression databases

    Genevestigatori Q5PPI4.

    Family and domain databases

    InterProi IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PROSITEi PS00310. LAMP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiLAMP5_RAT
    AccessioniPrimary (citable) accession number: Q5PPI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3