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Q5PPI4 (LAMP5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Brain and dendritic cell-associated LAMP
Brain-associated LAMP-like protein
Short name=BAD-LAMP
Lysosome-associated membrane protein 5
Short name=LAMP-5
Gene names
Name:Lamp5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane; Single-pass type I membrane protein By similarity. Recycling endosome By similarity. Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity.

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 280251Lysosome-associated membrane glycoprotein 5
PRO_0000360414

Regions

Topological domain30 – 235206Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 28024Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5PPI4 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 555111CD85C8A8FA

FASTA28031,505
        10         20         30         40         50         60 
MDLRGRALLG GDRLRILLMF FHAMAQTVAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 

        70         80         90        100        110        120 
EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGRCG HNESELQVFW VDRAYTLKML 

       130        140        150        160        170        180 
FVKESHNTSK GLEATWKLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGMSY 

       190        200        210        220        230        240 
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 

       250        260        270        280 
LGLILGLVIV ITLVIYHIHH KMTANQVQIP RDRSQYKHMG 

« Hide

References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH473949 Genomic DNA. Translation: EDL80298.1.
BC087680 mRNA. Translation: AAH87680.1.
RefSeqNP_001014205.1. NM_001014183.1.
UniGeneRn.13757.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5PPI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007274; ENSRNOP00000007274; ENSRNOG00000005457.
GeneID362220.
KEGGrno:362220.
UCSCRGD:1306991. rat.

Organism-specific databases

CTD24141.
RGD1306991. Lamp5.

Phylogenomic databases

eggNOGNOG41798.
GeneTreeENSGT00390000012584.
HOGENOMHOG000231912.
HOVERGENHBG051186.
InParanoidQ5PPI4.
OMACPVDERE.
OrthoDBEOG7DRJ3S.
PhylomeDBQ5PPI4.
TreeFamTF330776.

Gene expression databases

GenevestigatorQ5PPI4.

Family and domain databases

InterProIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio679076.
PROQ5PPI4.

Entry information

Entry nameLAMP5_RAT
AccessionPrimary (citable) accession number: Q5PPI4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 4, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families