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Q5PPI4

- LAMP5_RAT

UniProt

Q5PPI4 - LAMP5_RAT

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Protein

Lysosome-associated membrane glycoprotein 5

Gene

Lamp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Brain and dendritic cell-associated LAMP
Brain-associated LAMP-like protein
Short name:
BAD-LAMP
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:Lamp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1306991. Lamp5.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Endosome membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle By similarity. Cell projectiondendrite By similarity. Cell projectiongrowth cone membrane By similarity. Early endosome membrane By similarity; Single-pass type I membrane protein By similarity. Recycling endosome By similarity
Note: Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: UniProtKB
  2. dendrite membrane Source: UniProtKB
  3. early endosome membrane Source: UniProtKB
  4. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  5. endosome membrane Source: UniProtKB
  6. growth cone membrane Source: UniProtKB
  7. integral component of membrane Source: UniProtKB-KW
  8. plasma membrane Source: UniProtKB
  9. recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000360414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5PPI4.

Expressioni

Gene expression databases

GenevestigatoriQ5PPI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiQ5PPI4.
OMAiCPVDERE.
OrthoDBiEOG7DRJ3S.
PhylomeDBiQ5PPI4.
TreeFamiTF330776.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5PPI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLRGRALLG GDRLRILLMF FHAMAQTVAE QEVENLSGLS TNPEKDIFVV
60 70 80 90 100
RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGRCG
110 120 130 140 150
HNESELQVFW VDRAYTLKML FVKESHNTSK GLEATWKLSK VQFVYDSSEK
160 170 180 190 200
THFKDAVSAG KHTANSHHLS ALVTPAGMSY ECQAQQTISL ASSDPQKTVT
210 220 230 240 250
MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIV
260 270 280
ITLVIYHIHH KMTANQVQIP RDRSQYKHMG
Length:280
Mass (Da):31,505
Last modified:January 4, 2005 - v1
Checksum:i555111CD85C8A8FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473949 Genomic DNA. Translation: EDL80298.1.
BC087680 mRNA. Translation: AAH87680.1.
RefSeqiNP_001014205.1. NM_001014183.1.
UniGeneiRn.13757.

Genome annotation databases

EnsembliENSRNOT00000007274; ENSRNOP00000007274; ENSRNOG00000005457.
GeneIDi362220.
KEGGirno:362220.
UCSCiRGD:1306991. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473949 Genomic DNA. Translation: EDL80298.1 .
BC087680 mRNA. Translation: AAH87680.1 .
RefSeqi NP_001014205.1. NM_001014183.1.
UniGenei Rn.13757.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5PPI4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007274 ; ENSRNOP00000007274 ; ENSRNOG00000005457 .
GeneIDi 362220.
KEGGi rno:362220.
UCSCi RGD:1306991. rat.

Organism-specific databases

CTDi 24141.
RGDi 1306991. Lamp5.

Phylogenomic databases

eggNOGi NOG41798.
GeneTreei ENSGT00390000012584.
HOGENOMi HOG000231912.
HOVERGENi HBG051186.
InParanoidi Q5PPI4.
OMAi CPVDERE.
OrthoDBi EOG7DRJ3S.
PhylomeDBi Q5PPI4.
TreeFami TF330776.

Miscellaneous databases

NextBioi 679076.
PROi Q5PPI4.

Gene expression databases

Genevestigatori Q5PPI4.

Family and domain databases

InterProi IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PROSITEi PS00310. LAMP_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiLAMP5_RAT
AccessioniPrimary (citable) accession number: Q5PPI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3