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Protein

Eukaryotic translation initiation factor 2D

Gene

Eif2d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2D
Short name:
eIF2d
Alternative name(s):
Ligatin
Gene namesi
Name:Eif2d
Synonyms:Lgtn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1561765. Eif2d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Eukaryotic translation initiation factor 2DPRO_0000130614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity
Modified residuei241 – 2411PhosphoserineBy similarity
Modified residuei348 – 3481PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPG7.
PRIDEiQ5PPG7.

PTM databases

iPTMnetiQ5PPG7.

Expressioni

Gene expression databases

GenevisibleiQ5PPG7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006768.

Structurei

3D structure databases

ProteinModelPortaliQ5PPG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 17381PUAPROSITE-ProRule annotationAdd
BLAST
Domaini478 – 55174SUI1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF2D family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2522. Eukaryota.
ENOG410XSAV. LUCA.
GeneTreeiENSGT00550000074865.
HOVERGENiHBG006268.
InParanoidiQ5PPG7.
KOiK15027.
OMAiTVMKLPW.
OrthoDBiEOG73NG3R.
PhylomeDBiQ5PPG7.
TreeFamiTF105830.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR003121. SWIB_MDM2_domain.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
SSF55159. SSF55159. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
PS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKAFRVKS NTAIKGSDRR KLRADVTVAF PTLGTDQVSE LIPGKEELNV
60 70 80 90 100
VKLYAHKGDA VTVYTSGGNP ILFELEKNLY PTVYTLWSHP DLLPAFITWP
110 120 130 140 150
LVLEKLVGGA DLMLPGVVVP PTGLPQVQQG DLCAIALVGN RAPVAVGVAA
160 170 180 190 200
MSTAQMLASG LKGKGISVLH TYQDHLWRSG DKSSPPAIAP LDPTDSCEEK
210 220 230 240 250
ADLGLHGNLR SLSLEGEEEN GQVPNPEASD DPNSRALSQD SVDGKPLQEQ
260 270 280 290 300
MDELLEQCFL HALKSRVKKA DLPLLTSTLL GSHMFSCCPE GQQLDIKKSS
310 320 330 340 350
YKKLSKFLQH MQQEQIVQVK ELSKGVESIV AVDWRHPRIT SFIVPEPSLA
360 370 380 390 400
SQTVQEGSRE KPYLPPDIKS LYCVPANMTQ LFLESGHKKG STLEGSEVRR
410 420 430 440 450
IITDYAKRNN LVDADNRNLV KLDPILCDCI LEKNEQHLVM KLPWDSLLTR
460 470 480 490 500
CLKNLQPAYQ VTFPGQEPII KKGKLCPIDI TLVLKTYNKK VTVVRNLETY
510 520 530 540 550
GLDPCSVAAI LQQRCQASTI VSPAPGAKDS LQVQVQGNQI HHLGQLLLEE
560 570
YRLPGKYIQG LEKAPKPGKK
Length:570
Mass (Da):62,669
Last modified:January 4, 2005 - v1
Checksum:i97434C5FD17DD457
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087701 mRNA. Translation: AAH87701.1.
RefSeqiNP_001017489.1. NM_001017489.1.
UniGeneiRn.162387.

Genome annotation databases

EnsembliENSRNOT00000006768; ENSRNOP00000006768; ENSRNOG00000004910.
GeneIDi498225.
KEGGirno:498225.
UCSCiRGD:1561765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087701 mRNA. Translation: AAH87701.1.
RefSeqiNP_001017489.1. NM_001017489.1.
UniGeneiRn.162387.

3D structure databases

ProteinModelPortaliQ5PPG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006768.

PTM databases

iPTMnetiQ5PPG7.

Proteomic databases

PaxDbiQ5PPG7.
PRIDEiQ5PPG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006768; ENSRNOP00000006768; ENSRNOG00000004910.
GeneIDi498225.
KEGGirno:498225.
UCSCiRGD:1561765. rat.

Organism-specific databases

CTDi1939.
RGDi1561765. Eif2d.

Phylogenomic databases

eggNOGiKOG2522. Eukaryota.
ENOG410XSAV. LUCA.
GeneTreeiENSGT00550000074865.
HOVERGENiHBG006268.
InParanoidiQ5PPG7.
KOiK15027.
OMAiTVMKLPW.
OrthoDBiEOG73NG3R.
PhylomeDBiQ5PPG7.
TreeFamiTF105830.

Miscellaneous databases

PROiQ5PPG7.

Gene expression databases

GenevisibleiQ5PPG7. RN.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR003121. SWIB_MDM2_domain.
IPR001950. TIF_SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF47592. SSF47592. 1 hit.
SSF55159. SSF55159. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
PS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEIF2D_RAT
AccessioniPrimary (citable) accession number: Q5PPG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.