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Protein

Zinc finger protein 639

Gene

Znf639

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and may function as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 639
Gene namesi
Name:Znf639
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1585689. LOC683504.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Zinc finger protein 639PRO_0000383574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei88 – 881PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5PPG4.

PTM databases

iPTMnetiQ5PPG4.

Expressioni

Gene expression databases

GenevisibleiQ5PPG4. RN.

Interactioni

Subunit structurei

Interacts with CTNNA2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062807.

Structurei

3D structure databases

ProteinModelPortaliQ5PPG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni371 – 45585Interaction with CTNNA2By similarityAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri204 – 22724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39724C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000285973.
InParanoidiQ5PPG4.
OMAiMNEHPKK.
OrthoDBiEOG7W41BD.
PhylomeDBiQ5PPG4.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYPKKRKR KTLHPSRYSD SSGISRIADG VSGIFSDHCY SVCSMRQPDL
60 70 80 90 100
KYFDNKDDDS DPETANDLPK FTDGTKARSR SQSCLVPSPV LRILEHTVFS
110 120 130 140 150
TEKPADVEIC DEECGSPESG HQHTHEESPI EVHTSEDVPI AVEVHAISED
160 170 180 190 200
YDIEAENNSS ESLLDQTDEE PPAKLCKILD KSQASNVTAQ QKWPLLRANS
210 220 230 240 250
SGLYKCELCE FNSKYFSDLK QHVILKHKRT DSNVCRVCKE SFSTNMLLIE
260 270 280 290 300
HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS
310 320 330 340 350
SSELYLHFQE HSRDEQYLCQ FCEHETGDPE DLHSHVVNEH ARRLIELSDK
360 370 380 390 400
CGSGGHGQCS LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI
410 420 430 440 450
FPHVCDDCGK GFSSMLEYCK HLNSHLSEGI YLCQYCEYST GQIEDLKIHL
460 470 480
DFKHSADLPH KCSDCLMRFG NERELISHLP VHETT
Length:485
Mass (Da):55,532
Last modified:January 4, 2005 - v1
Checksum:i08836179B00514D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087704 mRNA. Translation: AAH87704.1.
RefSeqiNP_001074376.1. NM_001080907.2.
XP_006232316.1. XM_006232254.2.
XP_008759164.1. XM_008760942.1.
XP_008759165.1. XM_008760943.1.
UniGeneiRn.116062.

Genome annotation databases

EnsembliENSRNOT00000065518; ENSRNOP00000062807; ENSRNOG00000043053.
GeneIDi683504.
KEGGirno:683504.
UCSCiRGD:1585689. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087704 mRNA. Translation: AAH87704.1.
RefSeqiNP_001074376.1. NM_001080907.2.
XP_006232316.1. XM_006232254.2.
XP_008759164.1. XM_008760942.1.
XP_008759165.1. XM_008760943.1.
UniGeneiRn.116062.

3D structure databases

ProteinModelPortaliQ5PPG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062807.

PTM databases

iPTMnetiQ5PPG4.

Proteomic databases

PaxDbiQ5PPG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000065518; ENSRNOP00000062807; ENSRNOG00000043053.
GeneIDi683504.
KEGGirno:683504.
UCSCiRGD:1585689. rat.

Organism-specific databases

CTDi67778.
RGDi1585689. LOC683504.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000285973.
InParanoidiQ5PPG4.
OMAiMNEHPKK.
OrthoDBiEOG7W41BD.
PhylomeDBiQ5PPG4.

Miscellaneous databases

PROiQ5PPG4.

Gene expression databases

GenevisibleiQ5PPG4. RN.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN639_RAT
AccessioniPrimary (citable) accession number: Q5PPG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.