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Protein

Zinc finger protein 639

Gene

Znf639

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds DNA and may function as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 639
Gene namesi
Name:Znf639
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1585689. LOC683504.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003835741 – 485Zinc finger protein 639Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei88PhosphoserineBy similarity1
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5PPG4.

PTM databases

iPTMnetiQ5PPG4.
PhosphoSitePlusiQ5PPG4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000043053.
GenevisibleiQ5PPG4. RN.

Interactioni

Subunit structurei

Interacts with CTNNA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062807.

Structurei

3D structure databases

ProteinModelPortaliQ5PPG4.
SMRiQ5PPG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni371 – 455Interaction with CTNNA2By similarityAdd BLAST85

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri403 – 425C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 454C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri460 – 482C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063297.
HOGENOMiHOG000285973.
InParanoidiQ5PPG4.
OMAiFPHVCDD.
OrthoDBiEOG091G05F4.
PhylomeDBiQ5PPG4.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Q5PPG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYPKKRKR KTLHPSRYSD SSGISRIADG VSGIFSDHCY SVCSMRQPDL
60 70 80 90 100
KYFDNKDDDS DPETANDLPK FTDGTKARSR SQSCLVPSPV LRILEHTVFS
110 120 130 140 150
TEKPADVEIC DEECGSPESG HQHTHEESPI EVHTSEDVPI AVEVHAISED
160 170 180 190 200
YDIEAENNSS ESLLDQTDEE PPAKLCKILD KSQASNVTAQ QKWPLLRANS
210 220 230 240 250
SGLYKCELCE FNSKYFSDLK QHVILKHKRT DSNVCRVCKE SFSTNMLLIE
260 270 280 290 300
HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS
310 320 330 340 350
SSELYLHFQE HSRDEQYLCQ FCEHETGDPE DLHSHVVNEH ARRLIELSDK
360 370 380 390 400
CGSGGHGQCS LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI
410 420 430 440 450
FPHVCDDCGK GFSSMLEYCK HLNSHLSEGI YLCQYCEYST GQIEDLKIHL
460 470 480
DFKHSADLPH KCSDCLMRFG NERELISHLP VHETT
Length:485
Mass (Da):55,532
Last modified:January 4, 2005 - v1
Checksum:i08836179B00514D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087704 mRNA. Translation: AAH87704.1.
RefSeqiNP_001074376.1. NM_001080907.2.
XP_006232316.1. XM_006232254.2.
XP_008759164.1. XM_008760942.1.
XP_008759165.1. XM_008760943.1.
UniGeneiRn.116062.

Genome annotation databases

EnsembliENSRNOT00000065518; ENSRNOP00000062807; ENSRNOG00000043053.
GeneIDi683504.
KEGGirno:683504.
UCSCiRGD:1585689. rat.

Similar proteinsi

Entry informationi

Entry nameiZN639_RAT
AccessioniPrimary (citable) accession number: Q5PPG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families