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Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

Zgpat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 196C3H1-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH-type with G patch domain-containing protein
Gene namesi
Name:Zgpat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1310801 Zgpat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003851911 – 507Zinc finger CCCH-type with G patch domain-containing proteinAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphothreonineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPF5

Expressioni

Gene expression databases

BgeeiENSRNOG00000014235
GenevisibleiQ5PPF5 RN

Interactioni

Subunit structurei

Interacts with CHD4/Mi-2; the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019084

Structurei

3D structure databases

SMRiQ5PPF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 355G-patchPROSITE-ProRule annotationAdd BLAST47

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 196C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2185 Eukaryota
ENOG410Z4ZI LUCA
GeneTreeiENSGT00390000000732
HOGENOMiHOG000231955
InParanoidiQ5PPF5
OMAiRFKENCR
OrthoDBiEOG091G0FZN
PhylomeDBiQ5PPF5

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50103 ZF_C3H1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5PPF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDNLETAL QTYRAQLQQV ELALGAGLDA SEQADLRQLQ GDLKELIELT
60 70 80 90 100
EASLLSVRKS KLLSTVDQEH QEDAEYLAFQ KAIAEEAPVD PGNDSKTVPG
110 120 130 140 150
SEVQPTPTSS ALEEEEEDPD LEDLSGAKVN APYYSAWGTL EYHNAMVVGA
160 170 180 190 200
EEAEDGSACV RVLYLYPTHK SLKPCPFFLE GKCRFKENCR FSHGQLVSVD
210 220 230 240 250
ELRPFQDPDL SLLQTGSACL AKHQDGLWHP ARITDVDNGY YTVKFDSLLL
260 270 280 290 300
KEAVVEGDSI LPPLRTEATD SSDSDTGDAS DSSYARVVEA NTVDTGTCSS
310 320 330 340 350
AFAGWEVHTR GIGSKLLVKM GYEFGKGLGR HAEGRVEPIH AVVLPRGKSL
360 370 380 390 400
DQCAEILQKK TKQGQTGASR PPRCRRRSSR PEGRPPPRNV FDFLNEKLQS
410 420 430 440 450
QVPGTPDAGV DTPERRNKDM YHASKSAKQA LSLQLFQTEE KIERTQRDIR
460 470 480 490 500
GIQEALTRNT GRHGMATAHL QEKLEGAQRQ LGQLRAQEAD LQRKQRKADT

HRKMTEF
Length:507
Mass (Da):56,172
Last modified:January 4, 2005 - v1
Checksum:i4E46CB80553378B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087720 mRNA Translation: AAH87720.1
RefSeqiNP_001009656.1, NM_001009656.1
XP_006235811.1, XM_006235749.1
XP_006235812.1, XM_006235750.2
XP_006235813.1, XM_006235751.2
XP_006235814.1, XM_006235752.3
UniGeneiRn.8219

Genome annotation databases

EnsembliENSRNOT00000019084; ENSRNOP00000019084; ENSRNOG00000014235
GeneIDi296478
KEGGirno:296478
UCSCiRGD:1310801 rat

Similar proteinsi

Entry informationi

Entry nameiZGPAT_RAT
AccessioniPrimary (citable) accession number: Q5PPF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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