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Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

Zgpat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19627C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH-type with G patch domain-containing protein
Gene namesi
Name:Zgpat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1310801. Zgpat.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Zinc finger CCCH-type with G patch domain-containing proteinPRO_0000385191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei272 – 2721PhosphoserineBy similarity
Modified residuei276 – 2761PhosphothreonineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5PPF5.

Expressioni

Gene expression databases

GenevisibleiQ5PPF5. RN.

Interactioni

Subunit structurei

Interacts with CHD4/Mi-2; the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019084.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 35547G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19627C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2185. Eukaryota.
ENOG410Z4ZI. LUCA.
GeneTreeiENSGT00390000000732.
HOGENOMiHOG000231955.
InParanoidiQ5PPF5.
OMAiRFKENCR.
OrthoDBiEOG71RXK5.
PhylomeDBiQ5PPF5.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PPF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDNLETAL QTYRAQLQQV ELALGAGLDA SEQADLRQLQ GDLKELIELT
60 70 80 90 100
EASLLSVRKS KLLSTVDQEH QEDAEYLAFQ KAIAEEAPVD PGNDSKTVPG
110 120 130 140 150
SEVQPTPTSS ALEEEEEDPD LEDLSGAKVN APYYSAWGTL EYHNAMVVGA
160 170 180 190 200
EEAEDGSACV RVLYLYPTHK SLKPCPFFLE GKCRFKENCR FSHGQLVSVD
210 220 230 240 250
ELRPFQDPDL SLLQTGSACL AKHQDGLWHP ARITDVDNGY YTVKFDSLLL
260 270 280 290 300
KEAVVEGDSI LPPLRTEATD SSDSDTGDAS DSSYARVVEA NTVDTGTCSS
310 320 330 340 350
AFAGWEVHTR GIGSKLLVKM GYEFGKGLGR HAEGRVEPIH AVVLPRGKSL
360 370 380 390 400
DQCAEILQKK TKQGQTGASR PPRCRRRSSR PEGRPPPRNV FDFLNEKLQS
410 420 430 440 450
QVPGTPDAGV DTPERRNKDM YHASKSAKQA LSLQLFQTEE KIERTQRDIR
460 470 480 490 500
GIQEALTRNT GRHGMATAHL QEKLEGAQRQ LGQLRAQEAD LQRKQRKADT

HRKMTEF
Length:507
Mass (Da):56,172
Last modified:January 4, 2005 - v1
Checksum:i4E46CB80553378B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087720 mRNA. Translation: AAH87720.1.
RefSeqiNP_001009656.1. NM_001009656.1.
XP_006235811.1. XM_006235749.1.
XP_006235812.1. XM_006235750.1.
XP_006235813.1. XM_006235751.2.
XP_006235814.1. XM_006235752.2.
UniGeneiRn.8219.

Genome annotation databases

EnsembliENSRNOT00000019084; ENSRNOP00000019084; ENSRNOG00000014235.
GeneIDi296478.
KEGGirno:296478.
UCSCiRGD:1310801. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC087720 mRNA. Translation: AAH87720.1.
RefSeqiNP_001009656.1. NM_001009656.1.
XP_006235811.1. XM_006235749.1.
XP_006235812.1. XM_006235750.1.
XP_006235813.1. XM_006235751.2.
XP_006235814.1. XM_006235752.2.
UniGeneiRn.8219.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019084.

Proteomic databases

PaxDbiQ5PPF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019084; ENSRNOP00000019084; ENSRNOG00000014235.
GeneIDi296478.
KEGGirno:296478.
UCSCiRGD:1310801. rat.

Organism-specific databases

CTDi84619.
RGDi1310801. Zgpat.

Phylogenomic databases

eggNOGiKOG2185. Eukaryota.
ENOG410Z4ZI. LUCA.
GeneTreeiENSGT00390000000732.
HOGENOMiHOG000231955.
InParanoidiQ5PPF5.
OMAiRFKENCR.
OrthoDBiEOG71RXK5.
PhylomeDBiQ5PPF5.

Miscellaneous databases

PROiQ5PPF5.

Gene expression databases

GenevisibleiQ5PPF5. RN.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZGPAT_RAT
AccessioniPrimary (citable) accession number: Q5PPF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 4, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.