Reviewed, UniProtKB/Swiss-Prot Q5PP37 (ATXR2_ARATH)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase ATXR2
    EC=2.1.1.43
Alternative name(s):
    Trithorax-related protein 2
      Short name=TRX-related protein 2
    Protein SET DOMAIN GROUP 36

Gene names

Name:	ATXR2
Synonyms:	SDG36, SET36
Ordered Locus Names:	At3g21820
ORF Names:	MSD21.13

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 MYND-type zinc finger. Contains 1 SET domain.
Sequence caution	The sequence BAB02844.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Histone-lysine N-methyltransferase ATXR2		PRO_0000233359
Regions
	Domain	323 – 445	123	SET
	Zinc finger	134 – 203	70	MYND-type; degenerate

Sequences

	Sequence		Length	Mass (Da)
	Q5PP37-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 2EFE76512D6F74D7	FASTA	473	52,803
	10 20 30 40 50 60 MDSVYKTDEN FAADVAALLA PLPTPQLQEY FNKLITSRRC NGIEVKNNGT IGKGVYANSE 70 80 90 100 110 120 FDEDELILKD EILVGIQHSS NKVDCLVCSF CFRFIGSIEK QIGRKLYFKN LGVSGCCDDD 130 140 150 160 170 180 SSEEDECVKY NGNEEQCGGS SSSHNTLPEG VVSSLMNGEM ALPHTDKFPL PSPLSCPGGC 190 200 210 220 230 240 QEAFYCSESC AAADWESSHS LLCTGERSES ISREALGEFI KHANDTNDIF LLAAKAIAFT 250 260 270 280 290 300 ILRYRKLKAE HVDKKAKQSE PKQSLLLEAW KPVSIGYKRR WWDCIALPDD VDPTDEGAFR 310 320 330 340 350 360 MQIKNLACTS LELLKIAIFD KECEALFSLE IYGNIIGMFE LNNLDLVVAS PVEDYFLYID 370 380 390 400 410 420 DLPDAEKEET EEITRPFLDA LGDEYSDCCQ GTAFFPLQSC MNHSCCPNAK AFKREEDRDG 430 440 450 460 470 QAVIIALRRI SKNEEVTISY IDEELPYKER QALLADYGFS CKCSKCLEDS SSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Arabidopsis ORF clones." Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB025634 Genomic DNA. Translation: BAB02844.1. Sequence problems. BT020260 mRNA. Translation: AAV84481.1. BT021112 mRNA. Translation: AAX12882.1. AK221711 mRNA. Translation: BAD95436.1.
IPI	IPI00523213.
RefSeq	NP_188819.2.
UniGene	At.43333
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q5PP37.
Genome annotation databases
GeneID	821736.
GenomeReviews	Gene locus AT3G21820 in contig BA000014_GR.
KEGG	ath:AT3G21820.
NMPDR	fig|3702.1.peg.14424.
Organism-specific databases
TAIR	At3g21820.
Phylogenomic databases
OMA	SPVEDYF.
Enzyme and pathway databases
BRENDA	2.1.1.43. 302.
Gene expression databases
Genevestigator	Q5PP37.
Family and domain databases
InterPro	IPR001214. SET. IPR002893. Znf_MYND. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. PS01360. ZF_MYND_1. False negative. PS50865. ZF_MYND_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATXR2_ARATH

Accession

Primary (citable) accession number: Q5PP37
Secondary accession number(s): Q9LSY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	January 4, 2005
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)