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Q5PNS9

- P2C64_ARATH

UniProt

Q5PNS9 - P2C64_ARATH

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Protein

Probable protein phosphatase 2C 64

Gene

At4g38520

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Manganese 1By similarity
Metal bindingi86 – 861Manganese 2By similarity
Metal bindingi87 – 871Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi287 – 2871Manganese 2By similarity
Metal bindingi346 – 3461Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G38520-MONOMER.
ARA:GQT-2027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 64 (EC:3.1.3.16)
Short name:
AtPP2C64
Gene namesi
Ordered Locus Names:At4g38520
ORF Names:F20M13.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G38520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Probable protein phosphatase 2C 64PRO_0000367986Add
BLAST

Proteomic databases

PaxDbiQ5PNS9.
PRIDEiQ5PNS9.

Expressioni

Gene expression databases

GenevestigatoriQ5PNS9.

Interactioni

Protein-protein interaction databases

BioGridi15289. 1 interaction.
IntActiQ5PNS9. 1 interaction.
MINTiMINT-8390433.

Structurei

3D structure databases

ProteinModelPortaliQ5PNS9.
SMRiQ5PNS9. Positions 79-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 327247PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000238703.
InParanoidiQ5PNS9.
OMAiLEPHDQF.
PhylomeDBiQ5PNS9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PNS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSGLMNFLN ACLWPRSDQQ ARSASDSGGR QEGLLWFRDS GQHVFGDFSM
60 70 80 90 100
AVVQANSLLE DQSQLESGSL SSHDSGPFGT FVGVYDGHGG PETSRFINDH
110 120 130 140 150
MFHHLKRFTA EQQCMSSEVI KKAFQATEEG FLSIVTNQFQ TRPQIATVGS
160 170 180 190 200
CCLVSVICDG KLYVANAGDS RAVLGQVMRV TGEAHATQLS AEHNASIESV
210 220 230 240 250
RRELQALHPD HPDIVVLKHN VWRVKGIIQV SRSIGDVYLK RSEFNREPLY
260 270 280 290 300
AKFRLRSPFS KPLLSAEPAI TVHTLEPHDQ FIICASDGLW EHMSNQEAVD
310 320 330 340 350
IVQNHPRNGI AKRLVKVALQ EAAKKREMRY SDLKKIDRGV RRHFHDDITV
360 370 380 390 400
IVVFFDTNLV SRGSMLRGPA VSVRGAGVNL PHNTLAPCTT PTQAAAAGAS
Length:400
Mass (Da):44,123
Last modified:January 4, 2005 - v1
Checksum:i66AA091D20562CE3
GO

Sequence cautioni

The sequence CAB37508.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAB80516.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381R → S in AAL32532. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035540 Genomic DNA. Translation: CAB37508.1. Different initiation.
AL161593 Genomic DNA. Translation: CAB80516.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE86941.1.
CP002687 Genomic DNA. Translation: AEE86942.1.
AY062454 mRNA. Translation: AAL32532.1.
BT020368 mRNA. Translation: AAV85723.1.
BT021094 mRNA. Translation: AAX12864.1.
PIRiT05680.
RefSeqiNP_195564.2. NM_120013.5.
NP_974708.1. NM_202979.1.
UniGeneiAt.47543.

Genome annotation databases

EnsemblPlantsiAT4G38520.1; AT4G38520.1; AT4G38520.
AT4G38520.2; AT4G38520.2; AT4G38520.
GeneIDi830009.
KEGGiath:AT4G38520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035540 Genomic DNA. Translation: CAB37508.1 . Different initiation.
AL161593 Genomic DNA. Translation: CAB80516.1 . Different initiation.
CP002687 Genomic DNA. Translation: AEE86941.1 .
CP002687 Genomic DNA. Translation: AEE86942.1 .
AY062454 mRNA. Translation: AAL32532.1 .
BT020368 mRNA. Translation: AAV85723.1 .
BT021094 mRNA. Translation: AAX12864.1 .
PIRi T05680.
RefSeqi NP_195564.2. NM_120013.5.
NP_974708.1. NM_202979.1.
UniGenei At.47543.

3D structure databases

ProteinModelPortali Q5PNS9.
SMRi Q5PNS9. Positions 79-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 15289. 1 interaction.
IntActi Q5PNS9. 1 interaction.
MINTi MINT-8390433.

Proteomic databases

PaxDbi Q5PNS9.
PRIDEi Q5PNS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G38520.1 ; AT4G38520.1 ; AT4G38520 .
AT4G38520.2 ; AT4G38520.2 ; AT4G38520 .
GeneIDi 830009.
KEGGi ath:AT4G38520.

Organism-specific databases

TAIRi AT4G38520.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000238703.
InParanoidi Q5PNS9.
OMAi LEPHDQF.
PhylomeDBi Q5PNS9.

Enzyme and pathway databases

BioCyci ARA:AT4G38520-MONOMER.
ARA:GQT-2027-MONOMER.

Gene expression databases

Genevestigatori Q5PNS9.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C64_ARATH
AccessioniPrimary (citable) accession number: Q5PNS9
Secondary accession number(s): Q8W4N8, Q9SZN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 4, 2005
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3