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Q5PNS9

- P2C64_ARATH

UniProt

Q5PNS9 - P2C64_ARATH

Protein

Probable protein phosphatase 2C 64

Gene

At4g38520

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861Manganese 1By similarity
    Metal bindingi86 – 861Manganese 2By similarity
    Metal bindingi87 – 871Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi287 – 2871Manganese 2By similarity
    Metal bindingi346 – 3461Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G38520-MONOMER.
    ARA:GQT-2027-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 64 (EC:3.1.3.16)
    Short name:
    AtPP2C64
    Gene namesi
    Ordered Locus Names:At4g38520
    ORF Names:F20M13.80
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G38520.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Probable protein phosphatase 2C 64PRO_0000367986Add
    BLAST

    Proteomic databases

    PaxDbiQ5PNS9.
    PRIDEiQ5PNS9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5PNS9.

    Interactioni

    Protein-protein interaction databases

    BioGridi15289. 1 interaction.
    IntActiQ5PNS9. 1 interaction.
    MINTiMINT-8390433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PNS9.
    SMRiQ5PNS9. Positions 79-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 327247PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000238703.
    InParanoidiQ5PNS9.
    OMAiLEPHDQF.
    PhylomeDBiQ5PNS9.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5PNS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSGLMNFLN ACLWPRSDQQ ARSASDSGGR QEGLLWFRDS GQHVFGDFSM    50
    AVVQANSLLE DQSQLESGSL SSHDSGPFGT FVGVYDGHGG PETSRFINDH 100
    MFHHLKRFTA EQQCMSSEVI KKAFQATEEG FLSIVTNQFQ TRPQIATVGS 150
    CCLVSVICDG KLYVANAGDS RAVLGQVMRV TGEAHATQLS AEHNASIESV 200
    RRELQALHPD HPDIVVLKHN VWRVKGIIQV SRSIGDVYLK RSEFNREPLY 250
    AKFRLRSPFS KPLLSAEPAI TVHTLEPHDQ FIICASDGLW EHMSNQEAVD 300
    IVQNHPRNGI AKRLVKVALQ EAAKKREMRY SDLKKIDRGV RRHFHDDITV 350
    IVVFFDTNLV SRGSMLRGPA VSVRGAGVNL PHNTLAPCTT PTQAAAAGAS 400
    Length:400
    Mass (Da):44,123
    Last modified:January 4, 2005 - v1
    Checksum:i66AA091D20562CE3
    GO

    Sequence cautioni

    The sequence CAB37508.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAB80516.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381R → S in AAL32532. (PubMed:14593172)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035540 Genomic DNA. Translation: CAB37508.1. Different initiation.
    AL161593 Genomic DNA. Translation: CAB80516.1. Different initiation.
    CP002687 Genomic DNA. Translation: AEE86941.1.
    CP002687 Genomic DNA. Translation: AEE86942.1.
    AY062454 mRNA. Translation: AAL32532.1.
    BT020368 mRNA. Translation: AAV85723.1.
    BT021094 mRNA. Translation: AAX12864.1.
    PIRiT05680.
    RefSeqiNP_195564.2. NM_120013.5.
    NP_974708.1. NM_202979.1.
    UniGeneiAt.47543.

    Genome annotation databases

    EnsemblPlantsiAT4G38520.1; AT4G38520.1; AT4G38520.
    AT4G38520.2; AT4G38520.2; AT4G38520.
    GeneIDi830009.
    KEGGiath:AT4G38520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035540 Genomic DNA. Translation: CAB37508.1 . Different initiation.
    AL161593 Genomic DNA. Translation: CAB80516.1 . Different initiation.
    CP002687 Genomic DNA. Translation: AEE86941.1 .
    CP002687 Genomic DNA. Translation: AEE86942.1 .
    AY062454 mRNA. Translation: AAL32532.1 .
    BT020368 mRNA. Translation: AAV85723.1 .
    BT021094 mRNA. Translation: AAX12864.1 .
    PIRi T05680.
    RefSeqi NP_195564.2. NM_120013.5.
    NP_974708.1. NM_202979.1.
    UniGenei At.47543.

    3D structure databases

    ProteinModelPortali Q5PNS9.
    SMRi Q5PNS9. Positions 79-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 15289. 1 interaction.
    IntActi Q5PNS9. 1 interaction.
    MINTi MINT-8390433.

    Proteomic databases

    PaxDbi Q5PNS9.
    PRIDEi Q5PNS9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G38520.1 ; AT4G38520.1 ; AT4G38520 .
    AT4G38520.2 ; AT4G38520.2 ; AT4G38520 .
    GeneIDi 830009.
    KEGGi ath:AT4G38520.

    Organism-specific databases

    TAIRi AT4G38520.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000238703.
    InParanoidi Q5PNS9.
    OMAi LEPHDQF.
    PhylomeDBi Q5PNS9.

    Enzyme and pathway databases

    BioCyci ARA:AT4G38520-MONOMER.
    ARA:GQT-2027-MONOMER.

    Gene expression databases

    Genevestigatori Q5PNS9.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clones."
      Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C64_ARATH
    AccessioniPrimary (citable) accession number: Q5PNS9
    Secondary accession number(s): Q8W4N8, Q9SZN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3