Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. 2-succinylbenzoate--CoA ligase (menE)
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-554-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Protein family/group databases

ESTHERisalty-YFBB. MenH_SHCHC.
MEROPSiS33.996.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:SPA0555
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_0000341919Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5PN75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000028072.
KOiK08680.
OMAiLNDWYQQ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PN75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLHAQHMPG QPGAPSLVFL HGFSGDCREW QPVGEQFHGC SRLYIDLPGH
60 70 80 90 100
GGSAAIPVGG FADVIRLLRA TLISYNILKF WLVGYSLGGR VAMMAACQGI
110 120 130 140 150
PGLCGLVVEG GHPGLQNERA RAERRLSDGR WAERFRHEPL TEVFHDWYQQ
160 170 180 190 200
PVFASLTAQQ RQALTALRSQ NNGETLAAML EATSLAVQPD LREALNALAF
210 220 230 240 250
PFYYLCGERD SKFRALAQEV AATCHVIRNA GHNAHRENPA GVVDSLAQIL

RL
Length:252
Mass (Da):27,651
Last modified:January 4, 2005 - v1
Checksum:i4C7CC1C11AD277D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV76557.1.
RefSeqiWP_000979139.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV76557; AAV76557; SPA0555.
KEGGispt:SPA0555.
PATRICi32350281. VBISalEnt134188_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV76557.1.
RefSeqiWP_000979139.1. NC_006511.1.

3D structure databases

ProteinModelPortaliQ5PN75.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERisalty-YFBB. MenH_SHCHC.
MEROPSiS33.996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV76557; AAV76557; SPA0555.
KEGGispt:SPA0555.
PATRICi32350281. VBISalEnt134188_0590.

Phylogenomic databases

HOGENOMiHOG000028072.
KOiK08680.
OMAiLNDWYQQ.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.
BioCyciSENT295319:GJBZ-554-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMENH_SALPA
AccessioniPrimary (citable) accession number: Q5PN75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.