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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation
DNA bindingi853 – 87220H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-3378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:SPA3380
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901HTH-type transcriptional regulator MalTPRO_1000085776Add
BLAST

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5PM00.
SMRiQ5PM00. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini829 – 89466HTH luxR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PM00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALVTSP AGYGKTTLVS
60 70 80 90 100
QWAAGKNELG WYSLDEGDNQ QERFASYLIA AIQQATGGHC STSEAMAQKR
110 120 130 140 150
QYASLTSLFA QLFIELAQWH RPLYLVIDDY HLITNPVIHD AMRFFLRHQP
160 170 180 190 200
ENFTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFNHQE AKQFFDRRLS
210 220 230 240 250
SPIEAAESSR MCDDVAGWAT ALQLIALSAR QNHTSAHHSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL DNVDVSTRHF LLKSAILRSM NDALIVRVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDTGEWFSY HPLFGSFLRQ RCQWELAAEL PEIHRAAAES
360 370 380 390 400
WMEQGFPSEA IHHALAAGDA QMLRDILLNH AWGLFNHSEL ALLEESLKAL
410 420 430 440 450
PWESLLENPR LVLLQAWLMQ SQHRYSEVNT LLARAEQEIK GVMDGTLHAE
460 470 480 490 500
FNALRAQVAI NDGNPEEAER LAKLALDELP LAWFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLSQSLSL MQQTEQMARH HDVWHYALWS LIQQSEIQFA QGFLQAAWET
560 570 580 590 600
QERAFQLIKE QHLEQLPMHE FLVRIRAQLL WAWARLDEAE ASARSGIAVL
610 620 630 640 650
STFQPQQQLQ CLTLLVQCSL ARGDLDNARS QLNRLENLLG NGRYHCDWIS
660 670 680 690 700
NADKVRVIYW QLTGDKKSAA NWLRHTPKPA FANNHFLQGQ WRNIARAQIL
710 720 730 740 750
LGEFEPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ SGRKNDAQRV
760 770 780 790 800
LLDALQLANR TGFISHFVIE GEAMAQQLRQ LIQLNTLPEM EQHRAQRILR
810 820 830 840 850
EINQHHRHKF AHFDEGFVER LLNHPDVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNEQIAGEL AVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):103,016
Last modified:January 4, 2005 - v1
Checksum:iA85BD13270CA3366
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV79193.1.
RefSeqiWP_000907030.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV79193; AAV79193; SPA3380.
KEGGispt:SPA3380.
PATRICi32356394. VBISalEnt134188_3581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV79193.1.
RefSeqiWP_000907030.1. NC_006511.1.

3D structure databases

ProteinModelPortaliQ5PM00.
SMRiQ5PM00. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV79193; AAV79193; SPA3380.
KEGGispt:SPA3380.
PATRICi32356394. VBISalEnt134188_3581.

Phylogenomic databases

HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-3378-MONOMER.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_SALPA
AccessioniPrimary (citable) accession number: Q5PM00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 4, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.