Q5PL18 (UBIC_SALPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	SPA4050

Organism

Salmonella paratyphi A [Complete proteome] [HAMAP]

Taxonomic identifier

54388 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subunit structure	Monomer By similarity. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240569
Sites
	Binding site	35	1	Substrate; via amide nitrogen By similarity
	Binding site	77	1	Substrate By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PL18 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 98658AEEC6EF54D1	FASTA	165	18,720
	10 20 30 40 50 60 MSHPALTQLR ALRYFDAIPA LEPHLLDWLL LEDSMTKRFE QQGKRVSVTL IREAFVGQSE 70 80 90 100 110 120 VEEASGLLPS ESRYWLREIL LCADGEPWLA GRTVVPESTL CGPEQVLQHL GKTPLGRYLF 130 140 150 160 TSSTLTRDFI EIGRDATLWG RRSRLRLSGK PLLLTELFLP ASPLY

References

[1]

"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid." McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F. , Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W., Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M., Warren W., Florea L., Spieth J., Wilson R.K. Nat. Genet. 36:1268-1274(2004) [PubMed: 15531882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9150 / SARB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000026 Genomic DNA. Translation: AAV79796.1.
RefSeq	YP_153108.1. NC_006511.1.
3D structure databases
ProteinModelPortal	Q5PL18.
SMR	Q5PL18. Positions 2-165.
ModBase	Search...
Proteomic databases
PRIDE	Q5PL18.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3174914.
GenomeReviews	Gene locus SPA4050 in contig CP000026_GR.
KEGG	spt:SPA4050.
PATRIC	32357885. VBISalEnt134188_4294.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644467.
OMA	GRTVIPQ.
ProtClustDB	PRK11655.
Enzyme and pathway databases
BioCyc	SENT295319:SPA4050-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_SALPA

Accession

Primary (citable) accession number: Q5PL18

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program