Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-3078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:SPA3080
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168G/U mismatch-specific DNA glycosylasePRO_0000238682Add
BLAST

Proteomic databases

PRIDEiQ5PKX5.

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5PKX5.
SMRiQ5PKX5. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDG/mug DNA glycosylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000264684.
KOiK03649.
OMAiEVWVLPN.
OrthoDBiEOG68H872.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR015637. MUG/TDG.
IPR023502. MUG_bact.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PKX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKDILAPGL RVVFCGINPG LSSANTGFPF AHPANRFWKV IHLAGFTDRQ
60 70 80 90 100
LKPEEAEKLL DFRCGVTKLV DRPTVQATEV KLHELRSGGR NLIEKIEDYQ
110 120 130 140 150
PAALAVLGKQ AFEQGFSQRG IAWGKQKIAI GATMVWVLPN PSGLNRIKTE
160
KLVEAYRELD QALIMRGL
Length:168
Mass (Da):18,650
Last modified:January 4, 2005 - v1
Checksum:iA946974A29B16FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV78915.1.
RefSeqiWP_000237776.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV78915; AAV78915; SPA3080.
KEGGispt:SPA3080.
PATRICi32355768. VBISalEnt134188_3277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV78915.1.
RefSeqiWP_000237776.1. NC_006511.1.

3D structure databases

ProteinModelPortaliQ5PKX5.
SMRiQ5PKX5. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5PKX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV78915; AAV78915; SPA3080.
KEGGispt:SPA3080.
PATRICi32355768. VBISalEnt134188_3277.

Phylogenomic databases

HOGENOMiHOG000264684.
KOiK03649.
OMAiEVWVLPN.
OrthoDBiEOG68H872.

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-3078-MONOMER.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR015637. MUG/TDG.
IPR023502. MUG_bact.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiMUG_SALPA
AccessioniPrimary (citable) accession number: Q5PKX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 4, 2005
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.