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Q5PJ75

- Q5PJ75_SALPA

UniProt

Q5PJ75 - Q5PJ75_SALPA

Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Diphosphate + H2O = 2 phosphate.UniRule annotation

    Cofactori

    Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi66 – 661Magnesium 1UniRule annotation
    Metal bindingi71 – 711Magnesium 1UniRule annotation
    Metal bindingi71 – 711Magnesium 2UniRule annotation
    Metal bindingi103 – 1031Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciSENT295319:GJBZ-4228-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
    Alternative name(s):
    Pyrophosphate phospho-hydrolaseUniRule annotation
    Gene namesi
    Name:ppaUniRule annotationImported
    Ordered Locus Names:SPA4234Imported
    OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)Imported
    Taxonomic identifieri295319 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008185: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5PJ75.

    Interactioni

    Protein-protein interaction databases

    STRINGi295319.SPA4234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PJ75.
    SMRiQ5PJ75. Positions 2-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000236473.
    OMAiVEAIYIR.
    OrthoDBiEOG6NKR4X.

    Family and domain databases

    Gene3Di3.90.80.10. 1 hit.
    HAMAPiMF_00209. Inorganic_PPase.
    InterProiIPR008162. Pyrophosphatase.
    [Graphical view]
    PANTHERiPTHR10286. PTHR10286. 1 hit.
    PfamiPF00719. Pyrophosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF50324. SSF50324. 1 hit.
    PROSITEiPS00387. PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5PJ75-1 [UniParc]FASTAAdd to Basket

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    MSLLNVPAGK ELPEDIYVVI EIPANADPIK YEVDKESGAL FVDRFMSTAM    50
    FYPCNYGYIN HTLSLDGDPV DVLVPTPYPL QPGAVIRCRP VGVLKMTDES 100
    GEDAKLVAVP HTKLSKEYDH IKDVNDLPEL LKAQITHFFE HYKDLEKGKW 150
    VKVDGWDNAE AAKAEIVASF ERAAKK 176
    Length:176
    Mass (Da):19,677
    Last modified:January 4, 2005 - v1
    Checksum:i3C00EC5AA02B1BB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000026 Genomic DNA. Translation: AAV79970.1.
    RefSeqiYP_153282.1. NC_006511.1.

    Genome annotation databases

    EnsemblBacteriaiAAV79970; AAV79970; SPA4234.
    PATRICi32358279. VBISalEnt134188_4486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000026 Genomic DNA. Translation: AAV79970.1 .
    RefSeqi YP_153282.1. NC_006511.1.

    3D structure databases

    ProteinModelPortali Q5PJ75.
    SMRi Q5PJ75. Positions 2-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295319.SPA4234.

    Proteomic databases

    PRIDEi Q5PJ75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV79970 ; AAV79970 ; SPA4234 .
    PATRICi 32358279. VBISalEnt134188_4486.

    Phylogenomic databases

    HOGENOMi HOG000236473.
    OMAi VEAIYIR.
    OrthoDBi EOG6NKR4X.

    Enzyme and pathway databases

    BioCyci SENT295319:GJBZ-4228-MONOMER.

    Family and domain databases

    Gene3Di 3.90.80.10. 1 hit.
    HAMAPi MF_00209. Inorganic_PPase.
    InterProi IPR008162. Pyrophosphatase.
    [Graphical view ]
    PANTHERi PTHR10286. PTHR10286. 1 hit.
    Pfami PF00719. Pyrophosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50324. SSF50324. 1 hit.
    PROSITEi PS00387. PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9150 / SARB42Imported.

    Entry informationi

    Entry nameiQ5PJ75_SALPA
    AccessioniPrimary (citable) accession number: Q5PJ75
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3