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Q5PJ75

- Q5PJ75_SALPA

UniProt

Q5PJ75 - Q5PJ75_SALPA

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Protein
Inorganic pyrophosphatase
Gene
ppa, SPA4234
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi66 – 661Magnesium 1 By similarityUniRule annotation
Metal bindingi71 – 711Magnesium 1 By similarityUniRule annotation
Metal bindingi71 – 711Magnesium 2 By similarityUniRule annotation
Metal bindingi103 – 1031Magnesium 1 By similarityUniRule annotation

GO - Molecular functioni

  1. inorganic diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-4228-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Gene namesi
Name:ppaUniRule annotationImported
Ordered Locus Names:SPA4234Imported
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)Imported
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ5PJ75.

Interactioni

Protein-protein interaction databases

STRINGi295319.SPA4234.

Structurei

3D structure databases

ProteinModelPortaliQ5PJ75.
SMRiQ5PJ75. Positions 2-176.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000236473.
OMAiVEAIYIR.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PJ75-1 [UniParc]FASTAAdd to Basket

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MSLLNVPAGK ELPEDIYVVI EIPANADPIK YEVDKESGAL FVDRFMSTAM    50
FYPCNYGYIN HTLSLDGDPV DVLVPTPYPL QPGAVIRCRP VGVLKMTDES 100
GEDAKLVAVP HTKLSKEYDH IKDVNDLPEL LKAQITHFFE HYKDLEKGKW 150
VKVDGWDNAE AAKAEIVASF ERAAKK 176
Length:176
Mass (Da):19,677
Last modified:January 4, 2005 - v1
Checksum:i3C00EC5AA02B1BB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV79970.1.
RefSeqiYP_153282.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV79970; AAV79970; SPA4234.
PATRICi32358279. VBISalEnt134188_4486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV79970.1 .
RefSeqi YP_153282.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PJ75.
SMRi Q5PJ75. Positions 2-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295319.SPA4234.

Proteomic databases

PRIDEi Q5PJ75.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV79970 ; AAV79970 ; SPA4234 .
PATRICi 32358279. VBISalEnt134188_4486.

Phylogenomic databases

HOGENOMi HOG000236473.
OMAi VEAIYIR.
OrthoDBi EOG6NKR4X.

Enzyme and pathway databases

BioCyci SENT295319:GJBZ-4228-MONOMER.

Family and domain databases

Gene3Di 3.90.80.10. 1 hit.
HAMAPi MF_00209. Inorganic_PPase.
InterProi IPR008162. Pyrophosphatase.
[Graphical view ]
PANTHERi PTHR10286. PTHR10286. 1 hit.
Pfami PF00719. Pyrophosphatase. 1 hit.
[Graphical view ]
SUPFAMi SSF50324. SSF50324. 1 hit.
PROSITEi PS00387. PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiQ5PJ75_SALPA
AccessioniPrimary (citable) accession number: Q5PJ75
Entry historyi
Integrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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