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Protein

L-ribulose-5-phosphate 3-epimerase UlaE

Gene

ulaE

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.UniRule annotation

Catalytic activityi

L-ribulose 5-phosphate = L-xylulose 5-phosphate.UniRule annotation

Pathwayi: L-ascorbate degradation

This protein is involved in step 3 of the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Probable L-ascorbate-6-phosphate lactonase UlaG (ulaG)
  2. 3-keto-L-gulonate-6-phosphate decarboxylase UlaD (ulaD)
  3. L-ribulose-5-phosphate 3-epimerase UlaE (ulaE)
  4. L-ribulose-5-phosphate 4-epimerase UlaF (ulaF)
This subpathway is part of the pathway L-ascorbate degradation, which is itself part of Cofactor degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-ascorbate, the pathway L-ascorbate degradation and in Cofactor degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-4198-MONOMER.
UniPathwayiUPA00263; UER00379.

Names & Taxonomyi

Protein namesi
Recommended name:
L-ribulose-5-phosphate 3-epimerase UlaEUniRule annotation (EC:5.1.3.22UniRule annotation)
Alternative name(s):
L-ascorbate utilization protein EUniRule annotation
L-xylulose-5-phosphate 3-epimeraseUniRule annotation
Gene namesi
Name:ulaEUniRule annotation
Ordered Locus Names:SPA4204
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284L-ribulose-5-phosphate 3-epimerase UlaEPRO_0000233254Add
BLAST

Expressioni

Inductioni

Induced by L-ascorbate. Repressed by UlaR.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5PJ62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-ribulose-5-phosphate 3-epimerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000126090.
KOiK03079.
OMAiQAGMGHI.
OrthoDBiEOG6FFS58.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01951. UlaE.
InterProiIPR004560. L-Ru-5P_3-Epase.
IPR023492. L-Ru-5P_3-Epase_Enterobacteria.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00542. hxl6Piso_put. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PJ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKQIPLGI YEKALPAGEC WLERLRLAKT LGFDFVEMSV DETDARLARL
60 70 80 90 100
DWSREQRLAL VSAVAETGVR VPSMCLSAHR RFPLGSEDDA VRAQGLEIMR
110 120 130 140 150
KAIQFAQDVG IRVIQLAGYD VYYQQANDET RCRFRDGLKE SVDMASRAQV
160 170 180 190 200
TLAMEIMDYP LMNSISKALG YAHYLNNPWF QLYPDIGNLS AWDNDVQMEL
210 220 230 240 250
QAGIGHIVAV HVKDTKPGVF KNVPFGEGVV DFERCFETLK QSGYCGPYLI
260 270 280
EMWSETAENP AAEVAKARDW VKARMAKAGM VEAA
Length:284
Mass (Da):31,866
Last modified:January 4, 2005 - v1
Checksum:iBDBBC9223CC91217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV79941.1.
RefSeqiWP_000949529.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV79941; AAV79941; SPA4204.
KEGGispt:SPA4204.
PATRICi32358214. VBISalEnt134188_4454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV79941.1.
RefSeqiWP_000949529.1. NC_006511.1.

3D structure databases

ProteinModelPortaliQ5PJ62.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV79941; AAV79941; SPA4204.
KEGGispt:SPA4204.
PATRICi32358214. VBISalEnt134188_4454.

Phylogenomic databases

HOGENOMiHOG000126090.
KOiK03079.
OMAiQAGMGHI.
OrthoDBiEOG6FFS58.

Enzyme and pathway databases

UniPathwayiUPA00263; UER00379.
BioCyciSENT295319:GJBZ-4198-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01951. UlaE.
InterProiIPR004560. L-Ru-5P_3-Epase.
IPR023492. L-Ru-5P_3-Epase_Enterobacteria.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00542. hxl6Piso_put. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiULAE_SALPA
AccessioniPrimary (citable) accession number: Q5PJ62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 4, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.