Cytochrome c-552 precursor - Salmonella paratyphi A

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Reviewed, UniProtKB/Swiss-Prot Q5PJ02 (NRFA_SALPA)

Last modified November 4, 2008. Version 32. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c-552
    EC=1.7.2.2
Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
      Short name=Cytochrome c nitrite reductase

Gene names

Name:	nrfA
Ordered Locus Names:	SPA4094

Organism

Salmonella paratyphi A [Complete proteome] [HAMAP]

Taxonomic identifier

54388 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

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Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Plays a role in nitrite reduction By similarity.
Catalytic activity	NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).
Cofactor	Binds 1 calcium ion per monomer By similarity. Binds 5 heme groups covalently per monomer By similarity.
Pathway	Nitrogen metabolism; nitrate reduction (assimilation).
Subcellular location	PeriplasmBy similarity.
Sequence similarities	Belongs to the cytochrome c-552 family.

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Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Periplasm
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW nitrogen compound metabolic process Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: HAMAP
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nitrite reductase (cytochrome, ammonia-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 478

452

Cytochrome c-552

PRO_0000268973

Sites

Metal binding

Iron (heme 3 axial ligand) By similarity

Metal binding

126

Iron (heme 1 axial ligand) By similarity

Metal binding

164

Iron (heme 2 axial ligand) By similarity

Metal binding

213

Iron (heme 3 axial ligand) By similarity

Metal binding

215

Calcium By similarity

Metal binding

216

Calcium; via carbonyl oxygen By similarity

Metal binding

261

Calcium; via carbonyl oxygen By similarity

Metal binding

263

Calcium By similarity

Metal binding

275

Iron (heme 5 axial ligand) By similarity

Metal binding

286

Iron (heme 4 axial ligand) By similarity

Metal binding

301

Iron (heme 2 axial ligand) By similarity

Metal binding

318

Iron (heme 5 axial ligand) By similarity

Metal binding

393

Iron (heme 4 axial ligand) By similarity

Binding site

122

Heme 1 (covalent) By similarity

Binding site

125

Heme 1 (covalent) By similarity

Binding site

160

Heme 2 (covalent) By similarity

Binding site

163

Heme 2 (covalent) By similarity

Binding site

209

Heme 3 (covalent) By similarity

Binding site

212

Heme 3 (covalent) By similarity

Binding site

216

Substrate By similarity

Binding site

264

Substrate By similarity

Binding site

282

Heme 4 (covalent) By similarity

Binding site

285

Heme 4 (covalent) By similarity

Binding site

314

Heme 5 (covalent) By similarity

Binding site

317

Heme 5 (covalent) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q5PJ02-1 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 65D3E240FFEA9BA3
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FASTA

478

53,744

        10         20         30         40         50         60 
MARKTLRARR FFSLIFPFFF ITSVYAEQTP VSAKTVTVEA KNETFAPQHP DQYQSWKATS 

        70         80         90        100        110        120 
EQSAREDALA EDPRLVILWA GYPFSRDYNK PRGHAYAVTD VRETLRTGAP KTAEDGPLPM 

       130        140        150        160        170        180 
ACWSCKSPDV ALLIQQEGED GYFHGKWARG GPEIVNDLGC ADCHNTASDD FAQGKPALTL 

       190        200        210        220        230        240 
SRPYAERAME AISKPFDKAG RFDQQSMVCG QCHVEYYFDG KNKAVKFPWD EGMKVENMEQ 

       250        260        270        280        290        300 
YYDAIAFSDW TNSLSKTPML KAQHPEYETW SAGIHGKNNV TCIDCHMPKV QNAEGKLYTD 

       310        320        330        340        350        360 
HKIGNPFDNF AQTCANCHTQ DKASLQKVVA ERKQAIHDLK IKVEDQLVHA HFEAKAAWDA 

       370        380        390        400        410        420 
GATDAEMKPI LNDIRHAQWR WDLAIASHGI HMHAPEEGLR MLGSAMDKAA DARTKLARLL 

       430        440        450        460        470 
ATKGITHEIP LPDISTKEKA QKAIGLNMQQ INAEKQDFLK TVVPQWEDQA RKNSLLSQ

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References

[1]

"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid."
McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.

Wilson R.K.
Nat. Genet. 36:1268-1274(2004) [PubMed: 15531882] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9150 / SARB42.

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Cross-references

Sequence databases
	CP000026 Genomic DNA. Translation: AAV79838.1.
RefSeq	YP_153150.1.
3D structure databases
SMR	Q5PJ02. Positions 38-478.
ModBase	Search...
Genome annotation databases
GeneID	3177712.
GenomeReviews	Gene locus SPA4094 in contig CP000026_GR.
KEGG	spt:SPA4094.
NMPDR	fig\|295319.3.peg.4057.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5PJ02.
Enzyme and pathway databases
BioCyc	SENT295319:SPA4094-MON.
Family and domain databases
HAMAP	MF_01182. [Tree]
InterPro	IPR003321. Cyt_c552. IPR017570. Cytc_552_NO2Rdtase_formate-dep. IPR011031. Multihaem_cyt. [Graphical view]
Pfam	PF02335. Cytochrom_C552. 1 hit. [Graphical view]
PIRSF	PIRSF000243. Cyt_c552. 1 hit.
PROSITE	PS51008. MULTIHEME_CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

NRFA_SALPA

Accession

Primary (citable) accession number: Q5PJ02

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	January 4, 2005
Last modified:	November 4, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents