Q5PI07 (DCYD_SALPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-cysteine desulfhydrase
EC=4.4.1.15

Gene names

Name:	dcyD
Ordered Locus Names:	SPA0916

Organism

Salmonella paratyphi A (strain ATCC 9150 / SARB42) [Complete proteome] [HAMAP]

Taxonomic identifier

295319 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella paratyphi A

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine By similarity. HAMAP-Rule MF_01045
Catalytic activity	D-cysteine + H2O = H2S + NH3 + pyruvate. HAMAP-Rule MF_01045
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-amino acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	D-cysteine desulfhydrase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	D-cysteine desulfhydrase HAMAP-Rule MF_01045		PRO_1000064265
Amino acid modifications
	Modified residue	51	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PI07 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: EECC42CC46B5F25D	FASTA	328	34,889
	10 20 30 40 50 60 MPLHHLTRFP RLELIGAPTP LEYLPRLSDY PGREIYIKRD DVTPIAMGGN KLRKLEFLVA 70 80 90 100 110 120 DALREGADTL ITAGAIQSNH VRQTAAVAAK LGLHCVALLE NPIGTTAENY LTNGNRLLLD 130 140 150 160 170 180 LFNTQIEMCD VLTDPDAQLQ TLATRIEAQG FRPYVIPVGG SSALGAMGYV ESALEIAQQC 190 200 210 220 230 240 EEVVGLSSVV VASGSAGTHA GLAVGLEHLM PDVELIGVTV SRSVAEQKPK VIALQQAIAG 250 260 270 280 290 300 QLALTATADI HLWDDYFAPG YGVPNDAGME AVKLLASLEG VLLDPVYTGK AMAGLIDGIS 310 320 QKRFNDDGPI LFIHTGGAPA LFAYHPHV

References

[1]

"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid." McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F. , Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W., Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M., Warren W., Florea L., Spieth J., Wilson R.K. Nat. Genet. 36:1268-1274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9150 / SARB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000026 Genomic DNA. Translation: AAV76895.1.
RefSeq	YP_150207.1. NC_006511.1.
3D structure databases
HSSP	HSSP built from PDB template 1TYZ based on UniProtKB Q00740.
ProteinModelPortal	Q5PI07.
ModBase	Search...
Protein-protein interaction databases
STRING	295319.SPA0916.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAV76895; AAV76895; SPA0916.
GeneID	3174859.
KEGG	spt:SPA0916.
PATRIC	32351059. VBISalEnt134188_0969.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2515.
HOGENOM	HOG000022459.
KO	K05396.
OMA	PYLVPIG.
ProtClustDB	PRK03910.
Enzyme and pathway databases
BioCyc	SENT295319:GJBZ-916-MONOMER.
Family and domain databases
HAMAP	MF_01045. D-Cys_desulfhydr.
InterPro	IPR027278. ACCD_DCysDesulf. IPR005966. D-Cys_desShydrase. IPR023702. D_Cys_desulphydr_bac. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR01275. ACC_deam_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCYD_SALPA

Accession

Primary (citable) accession number: Q5PI07

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program