Reviewed,
UniProtKB/Swiss-Prot Q5PHC0 (ASTD_SALPA)
Last modified
February 9, 2010.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: N-succinylglutamate 5-semialdehyde dehydrogenase EC=1.2.1.71 Alternative name(s): Succinylglutamic semialdehyde dehydrogenase Short name=SGSD | ||||
| Gene names |
| ||||
| Organism | Salmonella paratyphi A [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 54388 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 492 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174 |
| Catalytic activity | N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174 |
| Pathway | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. AstD subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Arginine metabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 492 | 492 | N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174 | PRO_0000262420 | |||||
Regions | |||||||||
| Nucleotide binding | 220 – 225 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 243 | 1 | By similarity | ||||||
| Active site | 277 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid." McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F. Wilson R.K.Nat. Genet. 36:1268-1274(2004) [PubMed: 15531882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9150 / SARB42. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000026 Genomic DNA. Translation: AAV77472.1. |
| RefSeq | YP_150784.1. |
3D structure databases | |
| SMR | Q5PHC0. Positions 3-462. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3176125. |
| GenomeReviews | Gene locus SPA1539 in contig CP000026_GR. |
| KEGG | spt:SPA1539. |
| NMPDR | fig|295319.3.peg.1459. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG752218. |
| OMA | KAYHART. |
Enzyme and pathway databases | |
| BioCyc | SENT295319:SPA1539-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01174. Aldedh_AstD. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03240. arg_catab_astD. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ASTD_SALPA | ||||||||
| Accession | Primary (citable) accession number: Q5PHC0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


