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Q5PGR8

- NAGK_SALPA

UniProt

Q5PGR8 - NAGK_SALPA

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Protein
N-acetyl-D-glucosamine kinase
Gene
nagK, SPA1630
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Zinc By similarity
Metal bindingi177 – 1771Zinc By similarity
Metal bindingi179 – 1791Zinc By similarity
Metal bindingi184 – 1841Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATP Reviewed prediction
Nucleotide bindingi133 – 1408ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-1630-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:SPA1630
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303N-acetyl-D-glucosamine kinaseUniRule annotation
PRO_0000270112Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295319.SPA1630.

Structurei

3D structure databases

ProteinModelPortaliQ5PGR8.
SMRiQ5PGR8. Positions 1-303.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
OMAiMESINES.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PGR8-1 [UniParc]FASTAAdd to Basket

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MYYGFDIGGT KIALGVFDST RRLQWEKRVP TPHASYGAFL DAVCELVAEA    50
DQRFGVKGSV GIGIPGMPET EDGTLYAANV PAASGKPLRA DLSARLDRDV 100
RLDNDANCFA LSEAWDDEFT QYPLVMGLIL GTGVGGGLVL NGKPITGQSY 150
ITGEFGHMRL PVDALTLMGF DFPLRRCGCG QMGCIENYLS GRGFAWLYQH 200
YYHQSLQAPE IIALWEQGDE QAHAHVERYL DLLAVCLGNI LTIVDPDLLV 250
IGGGLSNFTA ITTQLAERLP RHLLPVARAP RIERARHGDA GGMRGAAFLH 300
LTD 303
Length:303
Mass (Da):32,964
Last modified:January 4, 2005 - v1
Checksum:i6ECC2357F621B447
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV77557.1.
RefSeqiYP_150869.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV77557; AAV77557; SPA1630.
PATRICi32352618. VBISalEnt134188_1737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV77557.1 .
RefSeqi YP_150869.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PGR8.
SMRi Q5PGR8. Positions 1-303.
ModBasei Search...

Protein-protein interaction databases

STRINGi 295319.SPA1630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV77557 ; AAV77557 ; SPA1630 .
PATRICi 32352618. VBISalEnt134188_1737.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
OMAi MESINES.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci SENT295319:GJBZ-1630-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiNAGK_SALPA
AccessioniPrimary (citable) accession number: Q5PGR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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