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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:SPA1814
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008185 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 162HelicalUniRule annotationAdd BLAST23
Transmembranei167 – 186HelicalUniRule annotationAdd BLAST20
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716511 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5PGH0.
SMRiQ5PGH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PGH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GIALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGKTD RSVLLWMPLV VIGLMILRGI TSYISSYCIS WVSGKVVMTM
110 120 130 140 150
RRRLFGHMMG MPVAFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG
160 170 180 190 200
ASIIGLFIMM FYYSWQLSII LVVLAPIVSI AIRVVSKRFR SISKNMQNTM
210 220 230 240 250
GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNKMRLQ GMKMVSASSI
260 270 280 290 300
SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
310 320 330 340 350
LTNVNAQFQR GMAACQTLFA ILDSEQEKDE GKRVIDRATG DLEFRNVTFT
360 370 380 390 400
YPGREVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGHI
410 420 430 440 450
LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEEYSREQI
460 470 480 490 500
EEAARMAYAM DFINKMDNGL DTIIGENGVL LSGGQRQRIA IARALLRDSP
510 520 530 540 550
ILILDEATSA LDTESERAIQ AALDELQKNR TSLMIAHRLS TIEQADEIVV
560 570 580
VEDGIIVERG THSELLAQHG VYAQLHKMQF GQ
Length:582
Mass (Da):64,372
Last modified:January 4, 2005 - v1
Checksum:iB8906F9CD650D538
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000026 Genomic DNA. Translation: AAV77730.1.
RefSeqiWP_000551245.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV77730; AAV77730; SPA1814.
KEGGispt:SPA1814.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SALPA
AccessioniPrimary (citable) accession number: Q5PGH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 4, 2005
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families