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Q5PG56 (6PGL_SALPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31
Gene names
Name:pgl
Ordered Locus Names:SPA1967
OrganismSalmonella paratyphi A [Complete proteome] [HAMAP]
Taxonomic identifier54388 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605

Catalytic activity

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605

Sequence similarities

Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: InterPro

   Molecular function6-phosphogluconolactonase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3313316-phosphogluconolactonase HAMAP MF_01605
PRO_0000171137

Sequences

Sequence LengthMass (Da)Tools
Q5PG56 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 84BAF66E97012D13

FASTA33136,351
        10         20         30         40         50         60 
MKQTVYTASP ESQQIHVWSL NHEGTLTLVQ VVDVPGQVQP MVVSPDKRYL YVGVRPEFRV 

        70         80         90        100        110        120 
LAYRIAPDDG ALTFAAESAL PGSPTHISTD HHGRFVFVGS YNAGNVSVTR LQDGLPVELV 

       130        140        150        160        170        180 
DVVEGLDGCH SANITPDNRT LWVPALKQER ICLFTLSDDG HLVAQEPAEV NTVEGAGPRH 

       190        200        210        220        230        240 
MVFHPNRQYA YCVNELNSSV DVWQLKNPHG EIECVQTLDM MPADFSDTRW AADIHITPDG 

       250        260        270        280        290        300 
RHLYACDRTA SLITVFSVSE DGSVLSVEGF QPTEAQPRGF NIDNSGKYLI AAGQKSHHIA 

       310        320        330 
VYEITGTQGL LTEKGRYAVG QGPMWVVVNA Y

« Hide

References

[1]"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid."
McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F. expand/collapse author list , Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W., Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M., Warren W., Florea L., Spieth J., Wilson R.K.
Nat. Genet. 36:1268-1274(2004) [PubMed: 15531882] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 9150 / SARB42.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000026 Genomic DNA. Translation: AAV77875.1.
RefSeqYP_151187.1. NC_006511.1.

3D structure databases

ProteinModelPortalQ5PG56.
SMRQ5PG56. Positions 1-331.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3175410.
GenomeReviewsGene locus SPA1967 in contig CP000026_GR.
KEGGspt:SPA1967.
NMPDRfig|295319.3.peg.675.
PATRIC32353357. VBISalEnt134188_2102.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG741123.
OMAFLISAGQ.
ProtClustDBPRK11028.

Enzyme and pathway databases

BioCycSENT295319:SPA1967-MONOMER.

Family and domain databases

HAMAPMF_01605. 6P-gluconolactonase.
[Tree]
InterProIPR022528. 6-phosphogluconolactonase_YbhE.
IPR019405. Lactonase_7-beta_prop.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KOK07404.
PfamPF10282. Lactonase. 1 hit.
[Graphical view]
SUPFAMSSF50974. N2O_reductase_N. 1 hit.
ProtoNetSearch...

Entry information

Entry name6PGL_SALPA
AccessionPrimary (citable) accession number: Q5PG56
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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