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Q5PEN7

- AAS_SALPA

UniProt

Q5PEN7 - AAS_SALPA

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Protein

Bifunctional protein Aas

Gene

aas

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361UniRule annotation

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid [acyl-carrier-protein] ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid metabolic process Source: InterPro
  2. phospholipid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Ligase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-2873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein AasUniRule annotation
Including the following 2 domains:
2-acylglycerophosphoethanolamine acyltransferaseUniRule annotation (EC:2.3.1.40UniRule annotation)
Alternative name(s):
2-acyl-GPE acyltransferaseUniRule annotation
Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferaseUniRule annotation
Acyl-[acyl-carrier-protein] synthetaseUniRule annotation (EC:6.2.1.20UniRule annotation)
Alternative name(s):
Acyl-ACP synthetaseUniRule annotation
Long-chain-fatty-acid--[acyl-carrier-protein] ligaseUniRule annotation
Gene namesi
Name:aasUniRule annotation
Ordered Locus Names:SPA2875
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Bifunctional protein AasPRO_0000193051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295319.SPA2875.

Structurei

3D structure databases

ProteinModelPortaliQ5PEN7.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei258 – 27720HelicalUniRule annotationAdd
BLAST
Transmembranei409 – 43325HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 138124AcyltransferaseAdd
BLAST
Regioni233 – 646414AMP-bindingAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.UniRule annotation
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000004907.
OMAiANWVYLE.
OrthoDBiEOG6KHFVG.

Family and domain databases

HAMAPiMF_01162. Aas.
InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PEN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFGFFRNLF RVLYRVRVTG DVRALQGNRV LITPNHVSFI DGMLLALFLP
60 70 80 90 100
VRPVFAVYTS ISQQWYMRWL TPLIDFVPLD PTKPMSIKHL MRLVEQGRPV
110 120 130 140 150
VIFPEGRISV TGSLMKIYDG AGFVAAKSGA TVIPLRIDGA ELTPFSRLKG
160 170 180 190 200
LVKRRLFPRI QLHILPPTQI PMPEAPRARD RRKIAGEMLH QIMMEARMAV
210 220 230 240 250
RPRETLYESL LAAQYRYGAG KNCIEDINFT PDTYRKLLTK TLFVGRILEK
260 270 280 290 300
YSVEGEKIGL MLPNAAISAA VIFGAVSRRR IPAMMNYTAG VKGLTSAIAA
310 320 330 340 350
AEIKTIFTSR QFLDKGKLWH LPEQLTQVRW VYLEDLKADV TLADKLWIFA
360 370 380 390 400
HLLAPRLAQV KQQPEDAAII LFTSGSEGHP KGVVHSHKSI LANVEQIKTI
410 420 430 440 450
ADFTANDRFM SALPLFHSFG LTVGLFTPLL TGAEVFLYPS PLHYRIVPEL
460 470 480 490 500
VYDRNCTVLF GTSTFLGNYA RFANPYDFYR LRYVVAGAEK LQESTKQLWQ
510 520 530 540 550
DKFGLRILEG YGVTECAPVV SINVPMAAKP GTVGRILPGM DARLLAVPGI
560 570 580 590 600
ENGGRLQLKG PNIMNGYLRV EKPGVLEVPS AENARGETER GWYDTGDIVR
610 620 630 640 650
FDENGFVQIQ GRAKRFAKIA GEMVSLEMVE QLALGVSADK MHATAIKSDA
660 670 680 690 700
SKGEALVLFT TDSELTREKL QHYAREHGIP ELAVPRDIRY LKQLPLLGSG
710
KPDFVTLKSW VDAPEQHHE
Length:719
Mass (Da):80,511
Last modified:January 4, 2005 - v1
Checksum:i7CEB9BAEF7475651
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78720.1.
RefSeqiYP_152032.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV78720; AAV78720; SPA2875.
PATRICi32355319. VBISalEnt134188_3055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78720.1 .
RefSeqi YP_152032.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PEN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295319.SPA2875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV78720 ; AAV78720 ; SPA2875 .
PATRICi 32355319. VBISalEnt134188_3055.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000004907.
OMAi ANWVYLE.
OrthoDBi EOG6KHFVG.

Enzyme and pathway databases

BioCyci SENT295319:GJBZ-2873-MONOMER.

Family and domain databases

HAMAPi MF_01162. Aas.
InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
Pfami PF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiAAS_SALPA
AccessioniPrimary (citable) accession number: Q5PEN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3