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Q5PEN7

- AAS_SALPA

UniProt

Q5PEN7 - AAS_SALPA

Protein

Bifunctional protein Aas

Gene

aas

Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.UniRule annotation

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
    ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361UniRule annotation

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. long-chain fatty acid [acyl-carrier-protein] ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid metabolic process Source: InterPro
    2. phospholipid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Ligase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT295319:GJBZ-2873-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein AasUniRule annotation
    Including the following 2 domains:
    2-acylglycerophosphoethanolamine acyltransferaseUniRule annotation (EC:2.3.1.40UniRule annotation)
    Alternative name(s):
    2-acyl-GPE acyltransferaseUniRule annotation
    Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferaseUniRule annotation
    Acyl-[acyl-carrier-protein] synthetaseUniRule annotation (EC:6.2.1.20UniRule annotation)
    Alternative name(s):
    Acyl-ACP synthetaseUniRule annotation
    Long-chain-fatty-acid--[acyl-carrier-protein] ligaseUniRule annotation
    Gene namesi
    Name:aasUniRule annotation
    Ordered Locus Names:SPA2875
    OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
    Taxonomic identifieri295319 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008185: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Bifunctional protein AasPRO_0000193051Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi295319.SPA2875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5PEN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei258 – 27720HelicalUniRule annotationAdd
    BLAST
    Transmembranei409 – 43325HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 138124AcyltransferaseAdd
    BLAST
    Regioni233 – 646414AMP-bindingAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.UniRule annotation
    In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000004907.
    OMAiANWVYLE.
    OrthoDBiEOG6KHFVG.

    Family and domain databases

    HAMAPiMF_01162. Aas.
    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR023775. Bifunctional_Aas.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PfamiPF01553. Acyltransferase. 1 hit.
    PF00501. AMP-binding. 1 hit.
    [Graphical view]
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5PEN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFGFFRNLF RVLYRVRVTG DVRALQGNRV LITPNHVSFI DGMLLALFLP    50
    VRPVFAVYTS ISQQWYMRWL TPLIDFVPLD PTKPMSIKHL MRLVEQGRPV 100
    VIFPEGRISV TGSLMKIYDG AGFVAAKSGA TVIPLRIDGA ELTPFSRLKG 150
    LVKRRLFPRI QLHILPPTQI PMPEAPRARD RRKIAGEMLH QIMMEARMAV 200
    RPRETLYESL LAAQYRYGAG KNCIEDINFT PDTYRKLLTK TLFVGRILEK 250
    YSVEGEKIGL MLPNAAISAA VIFGAVSRRR IPAMMNYTAG VKGLTSAIAA 300
    AEIKTIFTSR QFLDKGKLWH LPEQLTQVRW VYLEDLKADV TLADKLWIFA 350
    HLLAPRLAQV KQQPEDAAII LFTSGSEGHP KGVVHSHKSI LANVEQIKTI 400
    ADFTANDRFM SALPLFHSFG LTVGLFTPLL TGAEVFLYPS PLHYRIVPEL 450
    VYDRNCTVLF GTSTFLGNYA RFANPYDFYR LRYVVAGAEK LQESTKQLWQ 500
    DKFGLRILEG YGVTECAPVV SINVPMAAKP GTVGRILPGM DARLLAVPGI 550
    ENGGRLQLKG PNIMNGYLRV EKPGVLEVPS AENARGETER GWYDTGDIVR 600
    FDENGFVQIQ GRAKRFAKIA GEMVSLEMVE QLALGVSADK MHATAIKSDA 650
    SKGEALVLFT TDSELTREKL QHYAREHGIP ELAVPRDIRY LKQLPLLGSG 700
    KPDFVTLKSW VDAPEQHHE 719
    Length:719
    Mass (Da):80,511
    Last modified:January 4, 2005 - v1
    Checksum:i7CEB9BAEF7475651
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000026 Genomic DNA. Translation: AAV78720.1.
    RefSeqiYP_152032.1. NC_006511.1.

    Genome annotation databases

    EnsemblBacteriaiAAV78720; AAV78720; SPA2875.
    PATRICi32355319. VBISalEnt134188_3055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000026 Genomic DNA. Translation: AAV78720.1 .
    RefSeqi YP_152032.1. NC_006511.1.

    3D structure databases

    ProteinModelPortali Q5PEN7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 295319.SPA2875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV78720 ; AAV78720 ; SPA2875 .
    PATRICi 32355319. VBISalEnt134188_3055.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000004907.
    OMAi ANWVYLE.
    OrthoDBi EOG6KHFVG.

    Enzyme and pathway databases

    BioCyci SENT295319:GJBZ-2873-MONOMER.

    Family and domain databases

    HAMAPi MF_01162. Aas.
    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR023775. Bifunctional_Aas.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    Pfami PF01553. Acyltransferase. 1 hit.
    PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 9150 / SARB42.

    Entry informationi

    Entry nameiAAS_SALPA
    AccessioniPrimary (citable) accession number: Q5PEN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3