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Q5PEN7

- AAS_SALPA

UniProt

Q5PEN7 - AAS_SALPA

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Protein
Bifunctional protein Aas
Gene
aas, SPA2875
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 By similarity.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Source: UniProtKB-HAMAP
  3. long-chain fatty acid [acyl-carrier-protein] ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid metabolic process Source: InterPro
  2. phospholipid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Ligase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-2873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein Aas
Including the following 2 domains:
2-acylglycerophosphoethanolamine acyltransferase (EC:2.3.1.40)
Alternative name(s):
2-acyl-GPE acyltransferase
Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
Acyl-[acyl-carrier-protein] synthetase (EC:6.2.1.20)
Alternative name(s):
Acyl-ACP synthetase
Long-chain-fatty-acid--[acyl-carrier-protein] ligase
Gene namesi
Name:aas
Ordered Locus Names:SPA2875
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei258 – 27720Helical; Reviewed prediction
Add
BLAST
Transmembranei409 – 43325Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Bifunctional protein AasUniRule annotation
PRO_0000193051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295319.SPA2875.

Structurei

3D structure databases

ProteinModelPortaliQ5PEN7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 138124AcyltransferaseUniRule annotation
Add
BLAST
Regioni233 – 646414AMP-bindingUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000004907.
OMAiANWVYLE.
OrthoDBiEOG6KHFVG.

Family and domain databases

HAMAPiMF_01162. Aas.
InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PEN7-1 [UniParc]FASTAAdd to Basket

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MLFGFFRNLF RVLYRVRVTG DVRALQGNRV LITPNHVSFI DGMLLALFLP    50
VRPVFAVYTS ISQQWYMRWL TPLIDFVPLD PTKPMSIKHL MRLVEQGRPV 100
VIFPEGRISV TGSLMKIYDG AGFVAAKSGA TVIPLRIDGA ELTPFSRLKG 150
LVKRRLFPRI QLHILPPTQI PMPEAPRARD RRKIAGEMLH QIMMEARMAV 200
RPRETLYESL LAAQYRYGAG KNCIEDINFT PDTYRKLLTK TLFVGRILEK 250
YSVEGEKIGL MLPNAAISAA VIFGAVSRRR IPAMMNYTAG VKGLTSAIAA 300
AEIKTIFTSR QFLDKGKLWH LPEQLTQVRW VYLEDLKADV TLADKLWIFA 350
HLLAPRLAQV KQQPEDAAII LFTSGSEGHP KGVVHSHKSI LANVEQIKTI 400
ADFTANDRFM SALPLFHSFG LTVGLFTPLL TGAEVFLYPS PLHYRIVPEL 450
VYDRNCTVLF GTSTFLGNYA RFANPYDFYR LRYVVAGAEK LQESTKQLWQ 500
DKFGLRILEG YGVTECAPVV SINVPMAAKP GTVGRILPGM DARLLAVPGI 550
ENGGRLQLKG PNIMNGYLRV EKPGVLEVPS AENARGETER GWYDTGDIVR 600
FDENGFVQIQ GRAKRFAKIA GEMVSLEMVE QLALGVSADK MHATAIKSDA 650
SKGEALVLFT TDSELTREKL QHYAREHGIP ELAVPRDIRY LKQLPLLGSG 700
KPDFVTLKSW VDAPEQHHE 719
Length:719
Mass (Da):80,511
Last modified:January 4, 2005 - v1
Checksum:i7CEB9BAEF7475651
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78720.1.
RefSeqiYP_152032.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV78720; AAV78720; SPA2875.
PATRICi32355319. VBISalEnt134188_3055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78720.1 .
RefSeqi YP_152032.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PEN7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295319.SPA2875.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV78720 ; AAV78720 ; SPA2875 .
PATRICi 32355319. VBISalEnt134188_3055.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000004907.
OMAi ANWVYLE.
OrthoDBi EOG6KHFVG.

Enzyme and pathway databases

BioCyci SENT295319:GJBZ-2873-MONOMER.

Family and domain databases

HAMAPi MF_01162. Aas.
InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
Pfami PF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiAAS_SALPA
AccessioniPrimary (citable) accession number: Q5PEN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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