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Q5PEA9

- SPTP_SALPA

UniProt

Q5PEA9 - SPTP_SALPA

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Protein
Secreted effector protein SptP
Gene
sptP, SPA2736
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei481 – 4811Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Hydrolase, Protein phosphatase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-2734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted effector protein SptP
Including the following 2 domains:
GTPase-activating protein
Short name:
GAP
Tyrosine-protein phosphatase (EC:3.1.3.48)
Gene namesi
Name:sptP
Ordered Locus Names:SPA2736
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

Subcellular locationi

Secreted By similarity. Host cytoplasm By similarity
Note: Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cytoplasm By similarity.

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Secreted effector protein SptP
PRO_0000094864Add
BLAST

Interactioni

Subunit structurei

Forms a complex with SicP By similarity.

Protein-protein interaction databases

STRINGi295319.SPA2736.

Structurei

3D structure databases

ProteinModelPortaliQ5PEA9.
SMRiQ5PEA9. Positions 36-139, 167-539.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 543264Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 139105Chaperone-binding By similarity
Add
BLAST
Regioni167 – 290124GAP By similarity
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the YopE family.

Phylogenomic databases

eggNOGiNOG74835.
HOGENOMiHOG000028733.
OMAiWIDKAST.
OrthoDBiEOG6423BT.

Family and domain databases

Gene3Di1.20.120.260. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR011070. Globular_prot_asu/bsu.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR015203. SicP-binding.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR003546. Tyr_Pase_SptP/YopH.
IPR014773. Uncharacterised_dom_YopE.
[Graphical view]
PfamiPF09119. SicP-binding. 1 hit.
PF00102. Y_phosphatase. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47233. SSF47233. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF56568. SSF56568. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PEA9-1 [UniParc]FASTAAdd to Basket

« Hide

MLRYEERKLN NLTLSSFSKS GVSSDTRLYI AKENTDKAYV APEKFSSKVL    50
TWLGKMPLFK NTEVVQKHTE NIRVQNQKIL QTFLQALTEK YGEKAVNNAL 100
YMSSINMNKP LTQRLVVQIT ECVKGADGGF INIIKNKDNV GVMNAALVIK 150
GGDTKVTEQN NDVGAESKQP LLDIALKGLK RTIPQLEQMD GNSLRENFQE 200
MASGNGPLRS LMTNLQSLNK IPEAKQLNDY VTTLKNIQIG ADRFSQWGTC 250
GGEVERWIDK ASTHELTQAV KKIHVIAKEL KNVTAEFEKI KAGASMPQTM 300
NGPTLGLARF AVSSIPINQQ TQVKLSDGMP VPVNTLTFDG KPVALAGSYP 350
KNTPDALEAH MKMLLEKECS CLAVLTSEDQ MQAKQLPAYF RGSYTFGEVH 400
TNSQKVSSAS QGGAIDQYNM QLSCGEKRYT IPVLHVKNWP DHQPLPSTDQ 450
LEYLADRVKN SNQNGAPGRS SSDKHLPMIH CLGGVGRTGT MAAALVLKDN 500
PHSNLEQVRA DFRNSRNNRM LEDASQFVQL KAMQAQLLMT TAS 543
Length:543
Mass (Da):60,005
Last modified:January 4, 2005 - v1
Checksum:iBE20AFE173E8C1D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78593.1.
RefSeqiWP_000946993.1. NC_006511.1.
YP_151905.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV78593; AAV78593; SPA2736.
PATRICi32355024. VBISalEnt134188_2910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV78593.1 .
RefSeqi WP_000946993.1. NC_006511.1.
YP_151905.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PEA9.
SMRi Q5PEA9. Positions 36-139, 167-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295319.SPA2736.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV78593 ; AAV78593 ; SPA2736 .
PATRICi 32355024. VBISalEnt134188_2910.

Phylogenomic databases

eggNOGi NOG74835.
HOGENOMi HOG000028733.
OMAi WIDKAST.
OrthoDBi EOG6423BT.

Enzyme and pathway databases

BioCyci SENT295319:GJBZ-2734-MONOMER.

Family and domain databases

Gene3Di 1.20.120.260. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR011070. Globular_prot_asu/bsu.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR015203. SicP-binding.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR003546. Tyr_Pase_SptP/YopH.
IPR014773. Uncharacterised_dom_YopE.
[Graphical view ]
Pfami PF09119. SicP-binding. 1 hit.
PF00102. Y_phosphatase. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view ]
PRINTSi PR01371. BACYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47233. SSF47233. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF56568. SSF56568. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiSPTP_SALPA
AccessioniPrimary (citable) accession number: Q5PEA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Requires SicP as a chaperone for its stability and secretion By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi