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Q5PD72

- LPXB_SALPA

UniProt

Q5PD72 - LPXB_SALPA

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, SPA0236
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSENT295319:GJBZ-236-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:SPA0236
OrganismiSalmonella paratyphi A (strain ATCC 9150 / SARB42)
Taxonomic identifieri295319 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255222Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi295319.SPA0236.

Structurei

3D structure databases

ProteinModelPortaliQ5PD72.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5PD72-1 [UniParc]FASTAAdd to Basket

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MAAQRPLTIA LVAGETSGDI LGAGLIRALK ARVPNARFVG VAGPRMQAEG    50
CEAWYEMEEL AVMGIVEVLG RLRRLLHIRA DLTRRFTELK PDVFVGIDAP 100
DFNITLEGNL KKQGIKTIHY VSPSVWAWRQ KRVFKIGRST HMVLAFLPFE 150
KAFYDKFNVP CRFIGHTMAD AMPLDPDKNA ARDVLGIPHD AHCLALLPGS 200
RGAEVEMLSA DFLKTAQLLR QRYPDLEVVV PLVNAKRREQ FEKIKAEVAP 250
DLAVHLLDGM AREAMIASDA ALLASGTAAL ECMLAKCPMV VGYRMKSFTF 300
WLAKRLVKTE YVSLPNLLAG RELVKELLQE ECEPQKLAEA LLPLLANGKT 350
SHAMHDTFRE LHQQIRCNAD EQAADAVLEL AQ 382
Length:382
Mass (Da):42,442
Last modified:January 4, 2005 - v1
Checksum:i1877CFC14791F01E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV76265.1.
RefSeqiYP_149577.1. NC_006511.1.

Genome annotation databases

EnsemblBacteriaiAAV76265; AAV76265; SPA0236.
PATRICi32349580. VBISalEnt134188_0253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000026 Genomic DNA. Translation: AAV76265.1 .
RefSeqi YP_149577.1. NC_006511.1.

3D structure databases

ProteinModelPortali Q5PD72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 295319.SPA0236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV76265 ; AAV76265 ; SPA0236 .
PATRICi 32349580. VBISalEnt134188_0253.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SENT295319:GJBZ-236-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9150 / SARB42.

Entry informationi

Entry nameiLPXB_SALPA
AccessioniPrimary (citable) accession number: Q5PD72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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