Q5PC93 (RLMG_SALPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA large subunit methyltransferase G
EC=2.1.1.174

Alternative name(s):
23S rRNA m2G1835 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RlmG

Gene names

Name:	rlmG
Ordered Locus Names:	SPA3088

Organism

Salmonella paratyphi A [Complete proteome] [HAMAP]

Taxonomic identifier

54388 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA By similarity. HAMAP MF_01859
Catalytic activity	S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1835) in 23S rRNA. HAMAP MF_01859
Subcellular location	Cytoplasm Potential HAMAP MF_01859.
Sequence similarities	Belongs to the methyltransferase superfamily. RlmG family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Ribosomal RNA large subunit methyltransferase G HAMAP MF_01859		PRO_0000366497

Sequences

	Sequence		Length	Mass (Da)
	Q5PC93 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 6EA702A6A8803ADD	FASTA	378	42,272
	10 20 30 40 50 60 MSHVDDGFRS LTLKRFPQTD DVNPLLAWEA ADEYLLQQLD ETEIRGPVLI LNDTFGALSC 70 80 90 100 110 120 ALAEHSPYSI GDSYLSELGT RENLRHNGIA ESSVTFLDST ADYPQAPGVV LIKVPKTLAL 130 140 150 160 170 180 LEQQLRALRK VVTAQTRIIA GAKARDIHTS TLELFEKVLG PTTTTLAWKK ARLINCTFSH 190 200 210 220 230 240 PQLADAPQTL SWKLEDTGWT IHNHANVFSR TGLDIGARFF MQHLPENLDG EIVDLGCGNG 250 260 270 280 290 300 VIGLSLLAKN PQANVVFVDE SPMAVDSSRL NVETNLPEAF ERCEFMINNA LSGVEPFRFN 310 320 330 340 350 360 AVFCNPPFHQ KHALTDNIAW EMFHHARRCL KINGELYIVA NRHLDYFHKL KKIFGNCATI 370 ATNNKFVILK AVKQGRRR

References

[1]

"Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid." McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S., Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R., Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F. , Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W., Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M., Warren W., Florea L., Spieth J., Wilson R.K. Nat. Genet. 36:1268-1274(2004) [PubMed: 15531882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9150 / SARB42.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000026 Genomic DNA. Translation: AAV78922.1.
RefSeq	YP_152234.1. NC_006511.1.
3D structure databases
ProteinModelPortal	Q5PC93.
ModBase	Search...
Proteomic databases
PRIDE	Q5PC93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3176073.
GenomeReviews	Gene locus SPA3088 in contig CP000026_GR.
KEGG	spt:SPA3088.
PATRIC	32355786. VBISalEnt134188_3285.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG321931.
OMA	NRHLGYH.
ProtClustDB	PRK15001.
Enzyme and pathway databases
BioCyc	SENT295319:SPA3088-MONOMER.
Family and domain databases
HAMAP	MF_01859. 23SrRNA_methyltr_G. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR017237. rRNA_m2G-MeTrfase_RsmD. IPR007848. Small_mtfrase. [Graphical view]
KO	K11391.
Pfam	PF05175. MTS. 1 hit. [Graphical view]
PIRSF	PIRSF037565. RRNA_m2G_Mtase_RsmD_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMG_SALPA

Accession

Primary (citable) accession number: Q5PC93

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program