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Q5PB38

- SYL_ANAMM

UniProt

Q5PB38 - SYL_ANAMM

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Protein
Leucine--tRNA ligase
Gene
leuS, AM446
Organism
Anaplasma marginale (strain St. Maries)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei597 – 5971ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:AM446
OrganismiAnaplasma marginale (strain St. Maries)
Taxonomic identifieri234826 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
ProteomesiUP000006557: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotation
PRO_0000334727Add
BLAST

Proteomic databases

PRIDEiQ5PB38.

Interactioni

Protein-protein interaction databases

STRINGi234826.AM446.

Structurei

3D structure databases

ProteinModelPortaliQ5PB38.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi594 – 5985"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PB38-1 [UniParc]FASTAAdd to Basket

« Hide

MEFFGMGYNF KLVEQEIQKR WDFKIAGNDG INCYVLGMFP YPSGNIHMGH    50
IRNYTIGDVI ARYKRAHGLK VLHPIGWDAF GLPAENAALS YGVNPAVWTE 100
RNIESMRKQL KSIGISYNWD RELATCKEDY YKHEQAFFLD FLQQGLAYRK 150
ESWVNWDPVD NTVLANEQVV DGRGWRSGAK IERRKLSQWF LKITDFADSL 200
LDGLKTLDGW PEKVKLMQER WIGKTEGVIL EFATSCGQKL EVFSTMPHML 250
FGASFCAVSA EHPILRHVTD EAFSARVRGI IECSGDEEKQ KIGADTGLFA 300
THPLLDRKLP IYAANYVLSE YGTGAVFGCP AHDQRDFEFA VAHGLDIYQV 350
VFPDDGVQYD LQKEAYSGDG TYRNSEFLNG LRVDAARNAM IQKLESMGGC 400
RRVTNYRLHD WGISRQRYWG CPIPVVHCEK CGIVPVDRQD LPISLPEEVD 450
FSRGGNPLDH HPTWKHVQCP KCQSSAQRET DTFDTFFESS WYFAAFCSEQ 500
GGINAADCNK LLPVDYYIGG VEHAVLHLLY ARFFCRALKK CGHLAVEEPF 550
RNLITQGMVC HSVYRDAAGN YLFPEDAQRM IRDGEAVQRG KVEKMSKSKK 600
NVVDPSHIIK KYGADTVRLF MLSDTPPERD IEWSDVGVEG AWRYLERLWR 650
LFEDNSSIGA DFDTADVKAE DRVYLSGIHK LLRGLSADME HCRLNCAVAK 700
FREMSNTVFE MVKCGVSQQV INESVCILLR VMEPFIPHIA EKLWERIGGE 750
GMLCNRQWPS AREDLLTEDL VTIAVQVNGK LCSTLKVGAQ CDGEEVKAEA 800
LKVAQRKLGD KEVRNIYFVP GRVVNIVTK 829
Length:829
Mass (Da):94,109
Last modified:January 4, 2005 - v1
Checksum:iE5881D97AB91F66E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000030 Genomic DNA. Translation: AAV86492.1.
RefSeqiWP_011114276.1. NC_004842.2.
YP_153747.1. NC_004842.2.

Genome annotation databases

EnsemblBacteriaiAAV86492; AAV86492; AM446.
GeneIDi3171345.
KEGGiama:AM446.
PATRICi20946921. VBIAnaMar46146_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000030 Genomic DNA. Translation: AAV86492.1 .
RefSeqi WP_011114276.1. NC_004842.2.
YP_153747.1. NC_004842.2.

3D structure databases

ProteinModelPortali Q5PB38.
ModBasei Search...

Protein-protein interaction databases

STRINGi 234826.AM446.

Proteomic databases

PRIDEi Q5PB38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV86492 ; AAV86492 ; AM446 .
GeneIDi 3171345.
KEGGi ama:AM446.
PATRICi 20946921. VBIAnaMar46146_0386.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins."
    Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: St. Maries.

Entry informationi

Entry nameiSYL_ANAMM
AccessioniPrimary (citable) accession number: Q5PB38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi