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Q5PB38

- SYL_ANAMM

UniProt

Q5PB38 - SYL_ANAMM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Anaplasma marginale (strain St. Maries)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei597 – 5971ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:AM446
OrganismiAnaplasma marginale (strain St. Maries)
Taxonomic identifieri234826 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
ProteomesiUP000006557: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligasePRO_0000334727Add
BLAST

Proteomic databases

PRIDEiQ5PB38.

Interactioni

Protein-protein interaction databases

STRINGi234826.AM446.

Structurei

3D structure databases

ProteinModelPortaliQ5PB38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi594 – 5985"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5PB38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFFGMGYNF KLVEQEIQKR WDFKIAGNDG INCYVLGMFP YPSGNIHMGH
60 70 80 90 100
IRNYTIGDVI ARYKRAHGLK VLHPIGWDAF GLPAENAALS YGVNPAVWTE
110 120 130 140 150
RNIESMRKQL KSIGISYNWD RELATCKEDY YKHEQAFFLD FLQQGLAYRK
160 170 180 190 200
ESWVNWDPVD NTVLANEQVV DGRGWRSGAK IERRKLSQWF LKITDFADSL
210 220 230 240 250
LDGLKTLDGW PEKVKLMQER WIGKTEGVIL EFATSCGQKL EVFSTMPHML
260 270 280 290 300
FGASFCAVSA EHPILRHVTD EAFSARVRGI IECSGDEEKQ KIGADTGLFA
310 320 330 340 350
THPLLDRKLP IYAANYVLSE YGTGAVFGCP AHDQRDFEFA VAHGLDIYQV
360 370 380 390 400
VFPDDGVQYD LQKEAYSGDG TYRNSEFLNG LRVDAARNAM IQKLESMGGC
410 420 430 440 450
RRVTNYRLHD WGISRQRYWG CPIPVVHCEK CGIVPVDRQD LPISLPEEVD
460 470 480 490 500
FSRGGNPLDH HPTWKHVQCP KCQSSAQRET DTFDTFFESS WYFAAFCSEQ
510 520 530 540 550
GGINAADCNK LLPVDYYIGG VEHAVLHLLY ARFFCRALKK CGHLAVEEPF
560 570 580 590 600
RNLITQGMVC HSVYRDAAGN YLFPEDAQRM IRDGEAVQRG KVEKMSKSKK
610 620 630 640 650
NVVDPSHIIK KYGADTVRLF MLSDTPPERD IEWSDVGVEG AWRYLERLWR
660 670 680 690 700
LFEDNSSIGA DFDTADVKAE DRVYLSGIHK LLRGLSADME HCRLNCAVAK
710 720 730 740 750
FREMSNTVFE MVKCGVSQQV INESVCILLR VMEPFIPHIA EKLWERIGGE
760 770 780 790 800
GMLCNRQWPS AREDLLTEDL VTIAVQVNGK LCSTLKVGAQ CDGEEVKAEA
810 820
LKVAQRKLGD KEVRNIYFVP GRVVNIVTK
Length:829
Mass (Da):94,109
Last modified:January 4, 2005 - v1
Checksum:iE5881D97AB91F66E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000030 Genomic DNA. Translation: AAV86492.1.
RefSeqiYP_153747.1. NC_004842.2.

Genome annotation databases

EnsemblBacteriaiAAV86492; AAV86492; AM446.
GeneIDi3171345.
KEGGiama:AM446.
PATRICi20946921. VBIAnaMar46146_0386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000030 Genomic DNA. Translation: AAV86492.1 .
RefSeqi YP_153747.1. NC_004842.2.

3D structure databases

ProteinModelPortali Q5PB38.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234826.AM446.

Proteomic databases

PRIDEi Q5PB38.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV86492 ; AAV86492 ; AM446 .
GeneIDi 3171345.
KEGGi ama:AM446.
PATRICi 20946921. VBIAnaMar46146_0386.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins."
    Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: St. Maries.

Entry informationi

Entry nameiSYL_ANAMM
AccessioniPrimary (citable) accession number: Q5PB38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3