Reviewed, UniProtKB/Swiss-Prot Q5PB25 (PSD_ANAMM)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	AM463

Organism

Anaplasma marginale (strain St. Maries) [Complete proteome] [HAMAP]

Taxonomic identifier

234826 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000262179
	Chain	181 – 227	47	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000262180
Sites
	Site	180 – 181	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	181	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5PB25-1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: E26793922DF1CDC3	FASTA	227	24,019
	10 20 30 40 50 60 MSFPSIHRHG YPFICLAFLC SCIGFALSSS LGVIFAMITA LCAYFFRDPI RVIPLNDALV 70 80 90 100 110 120 ASPADGVVTS IVEVESPLND GKTVTRISIF LSLFDVHVNR VPVSGVVKSV EHRPGSFSSA 130 140 150 160 170 180 GSGGAVNENE RVRAVIESSV GGHCIVVEQI AGVLARRIVC DLESGKAAKL GSRMGIIRFG 190 200 210 220 SRMNIYIPAG MPVSVAEGHT VVGGETIIAS LDADMATVHK DLTFDKV

References

[1]

"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins." Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr. Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed: 15618402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000030 Genomic DNA. Translation: AAV86505.1. Different initiation.
RefSeq	YP_153760.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5PB25.
Genome annotation databases
GeneID	3171333.
GenomeReviews	Gene locus AM463 in contig CP000030_GR.
KEGG	ama:AM463.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5PB25.
OMA	DKASEDN.
Enzyme and pathway databases
BioCyc	AMAR234826:AM463-MON.
Family and domain databases
HAMAP	MF_00664. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase_related. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_ANAMM

Accession

Primary (citable) accession number: Q5PB25

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)