Reviewed, UniProtKB/Swiss-Prot Q5PAN5 (PYRB_ANAMM)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	AM662

Organism

Anaplasma marginale (strain St. Maries) [Complete proteome] [HAMAP]

Taxonomic identifier

234826 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113085

Sequences

	Sequence		Length	Mass (Da)
	Q5PAN5-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 6B6AF3952B9C4A50	FASTA	298	32,701
	10 20 30 40 50 60 MGNLKKLLRV SDLSDEDVEN LLILANKYMA QEASDEVLRG KVIVNLFFES STRTLLAFEI 70 80 90 100 110 120 AEKALGAISV TLNVAMSSIC KGESISDTMS TMAAMGTDLV VVRSDQSCMV DEIAKRAGDC 130 140 150 160 170 180 LVINAGDGNH EHPTQAITDY ATIRSLKGGE VRGLKVAICG DVFHSRVARS NIRLLSRYGA 190 200 210 220 230 240 DIRVVTPMRV DHVPDGVSLV TRSLEEGIEG ADVIMLLRIQ RERMTNGDFM LDKEYSRLYM 250 260 270 280 290 LDEKRLSLAK DDVIVMHPGP MNRGVEISDE VADNHSSVLF QVKVGAAVRK AVLHYMLG

References

[1]

"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins." Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr. Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed: 15618402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000030 Genomic DNA. Translation: AAV86645.1.
RefSeq	YP_153900.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3171391.
GenomeReviews	Gene locus AM662 in contig CP000030_GR.
KEGG	ama:AM662.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5PAN5.
OMA	Q5PAN5. RTVVNLF.
Enzyme and pathway databases
BioCyc	AMAR234826:AM662-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ANAMM

Accession

Primary (citable) accession number: Q5PAN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)