Reviewed, UniProtKB/Swiss-Prot Q5PAM4 (SYR_ANAMM)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	AM678

Organism

Anaplasma marginale (strain St. Maries) [Complete proteome] [HAMAP]

Taxonomic identifier

234826 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000241976
Regions
	Motif	136 – 146	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q5PAM4-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 015D7CDA3EE81DD0	FASTA	579	64,676
	10 20 30 40 50 60 MVSAGSTINL FGNFRCIVIQ KIGELWGGEV TDSLLHKLIV APPTEDRHGD VYTNAALVVG 70 80 90 100 110 120 KFKRKNPMEI AEHLRQALAE VEGVDSVDVV PPGFVNLKCS NEVWYSAIRD INKAGKDYGA 130 140 150 160 170 180 VNLGQGQKVN VEFVSANPTG PLHIGHARGA VFGDVLSNLL AWVGYDVTRE YYVNDAGGQI 190 200 210 220 230 240 NTLVESVYLR YKEALGEQVT IGEGLYPGEY LKPIAKALVE KHGDKLLASE DRTAVIREFA 250 260 270 280 290 300 LKSILDLIRE DMALLGVKHD VFTYEADLQR SRTVEKCVEF LQQKGMLYYG TLERPRGVEE 310 320 330 340 350 360 EAAWQAREQL LFRSTDFGDD SDRALQKEDG SWTYFAGDIA YHFDKISRGF HDMILGLGFD 370 380 390 400 410 420 HKGYVSRLKA AVHALSDGKA TIDVKLHNMV NFLENGVPVK MSKRRGEFLT ARDVVEEVGK 430 440 450 460 470 480 DVARFIMMTR KNDVVLDFDF AKAKEQSKDS QIFYIQYAHA RACSLMRNAP TLLPIEDVDF 490 500 510 520 530 540 SRVSSAPEIA LIKLLVRWPN IVESSAVNHE PHRIAFYLLE VAEAFHVLWG HGSRSVDMRF 550 560 570 IVEGDIATTS ARIYLVKVVA LVISLGLSIF SIAPMEEMR

References

[1]

"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins." Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr. Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed: 15618402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000030 Genomic DNA. Translation: AAV86656.1.
RefSeq	YP_153911.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5PAM4.
Genome annotation databases
GeneID	3171804.
GenomeReviews	Gene locus AM678 in contig CP000030_GR.
KEGG	ama:AM678.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5PAM4.
OMA	ADHHGYV.
Enzyme and pathway databases
BioCyc	AMAR234826:AM678-MON.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ANAMM

Accession

Primary (citable) accession number: Q5PAM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 4, 2005
Last modified:	November 3, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)