Q5P9K5 (SYY_ANAMM) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 43.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine--tRNA ligase EC=6.1.1.1 Alternative name(s): Tyrosyl-tRNA synthetase Short name=TyrRS | ||||
| Gene names |
| ||||
| Organism | Anaplasma marginale (strain St. Maries) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 234826 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma |
Protein attributes
| Sequence length | 414 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) By similarity. HAMAP MF_02006 |
| Catalytic activity | ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). HAMAP MF_02006 |
| Subunit structure | Homodimer By similarity. HAMAP MF_02006 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_02006. |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. Contains 1 S4 RNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding RNA-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tyrosyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA bindingInferred from electronic annotation. Source: UniProtKB-KW tyrosine-tRNA ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 414 | 414 | Tyrosine--tRNA ligase HAMAP MF_02006 | PRO_0000234665 | |||||
Regions | |||||||||
| Domain | 345 – 412 | 68 | S4 RNA-binding | ||||||
| Motif | 43 – 52 | 10 | "HIGH" region HAMAP MF_02006 | ||||||
| Motif | 232 – 236 | 5 | "KMSKS" region HAMAP MF_02006 | ||||||
Sites | |||||||||
| Binding site | 38 | 1 | Tyrosine By similarity | ||||||
| Binding site | 172 | 1 | Tyrosine By similarity | ||||||
| Binding site | 176 | 1 | Tyrosine By similarity | ||||||
| Binding site | 235 | 1 | ATP By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins." Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr. Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed: 15618402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: St. Maries. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000030 Genomic DNA. Translation: AAV87025.1. |
| RefSeq | YP_154280.1. NC_004842.2. |
3D structure databases | |
| ProteinModelPortal | Q5P9K5. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5P9K5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3171475. |
| GenomeReviews | Gene locus AM1205 in contig CP000030_GR. |
| KEGG | ama:AM1205. |
| PATRIC | 20948261. VBIAnaMar46146_1041. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0162. |
| HOGENOM | HBG288125. |
| OMA | HEVIILL. |
| PhylomeDB | Q5P9K5. |
| ProtClustDB | PRK05912. |
Enzyme and pathway databases | |
| BioCyc | AMAR234826:AM1205-MONOMER. |
Family and domain databases | |
| HAMAP | MF_02006. Tyr_tRNA_synth_type1. [Tree] |
| InterPro | IPR002305. aa-tRNA-synth_Ic. IPR014729. Rossmann-like_a/b/a_fold. IPR002942. S4_RNA-bd. IPR002307. Tyr-tRNA-synth. IPR024088. Tyr-tRNA-synth_bac-type. IPR024107. Tyr-tRNA-synth_bac_1. [Graphical view] |
| Gene3D | G3DSA:3.10.290.10. G3DSA:3.10.290.10. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| KO | K01866. |
| PANTHER | PTHR11766. Tyr_tRNA-synt_1b. 1 hit. |
| Pfam | PF00579. tRNA-synt_1b. 1 hit. [Graphical view] |
| PRINTS | PR01040. TRNASYNTHTYR. |
| SMART | SM00363. S4. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00234. TyrS. 1 hit. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. False negative. PS50889. S4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYY_ANAMM | ||||||||
| Accession | Primary (citable) accession number: Q5P9K5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with