Q5P9A6 (PTH_ANAMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	AM1339

Organism

Anaplasma marginale (strain St. Maries) [Complete proteome] [HAMAP]

Taxonomic identifier

234826 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Anaplasma

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity. HAMAP MF_00083
Subcellular location	Cytoplasm By similarity HAMAP MF_00083.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187679

Sequences

	Sequence		Length	Mass (Da)
	Q5P9A6 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: E4491C3C83637705	FASTA	186	20,090
	10 20 30 40 50 60 MLLLVGLGNP GKQYEFTRHN VGFVVADTVA RDFNFPEFSS KYDALVSVGN VGLHRAMIVK 70 80 90 100 110 120 PATFMNRSGA AVLKAASMHK IPAEQITVFH DDADLQHGVV KVKQGGGNAG HNGLRSIDAA 130 140 150 160 170 180 IGCQYWRVRL GVGRPDVGSL SGHVLSDFHD FDSVQQLAHK ISANLTELLD GNVNGFISKI RCDHAQ

References

[1]

"Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins." Brayton K.A., Kappmeyer L.S., Herndon D.R., Dark M.J., Tibbals D.L., Palmer G.H., McGuire T.C., Knowles D.P. Jr. Proc. Natl. Acad. Sci. U.S.A. 102:844-849(2005) [PubMed: 15618402] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: St. Maries.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000030 Genomic DNA. Translation: AAV87124.1.
RefSeq	YP_154379.1. NC_004842.2.
3D structure databases
ProteinModelPortal	Q5P9A6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P9A6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3171042.
GenomeReviews	Gene locus AM1339 in contig CP000030_GR.
KEGG	ama:AM1339.
PATRIC	20948497. VBIAnaMar46146_1157.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HBG610927.
OMA	IKFKTGG.
PhylomeDB	Q5P9A6.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	AMAR234826:AM1339-MONOMER.
Family and domain databases
HAMAP	MF_00083. Pept_tRNA_hydro_bact. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
KO	K01056.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. Pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_ANAMM

Accession

Primary (citable) accession number: Q5P9A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	January 4, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program