Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAARO76114:GJTA-441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotationImported)
Gene namesi
Name:icdImported
ORF Names:ebA829Imported
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))Imported
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA829.

Structurei

3D structure databases

ProteinModelPortaliQ5P804.
SMRiQ5P804. Positions 4-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSHITVPT GGQKIIPGQP IPDNPIIPFI EGDGIGVDIT PVMIKVIDAA
60 70 80 90 100
VAKAYGGKRK IHWMEVYAGE KSTQVYGPDE WLSKETLDAL KEYSVSIKGP
110 120 130 140 150
MTTPVGGGIR SLNVALRQEL DLYQCVRPIQ YFKGVPSPLK NPELTNMVIF
160 170 180 190 200
RENTEDIYAG IEWQADSEQA RKVIAFLQNE MGVRKIRFPA TSGIGIKPVS
210 220 230 240 250
VEGTQRLVRA ALKYVIDNDR KSLTIVHKGN IMKFTEGLFR DVAYELAQKE
260 270 280 290 300
FGAQPIDGGP WCKFKNPNTG REIVVKDSIA DAFLQQILLR PAEYDVIATT
310 320 330 340 350
NLNGDYISDA LAAQVGGIGI APGANISDQY ACFEATHGTA PKYAGLDKVN
360 370 380 390 400
PGSLILSAEM MLRFMKWTEA ADLVIKGMEA AIGDKVVTYD FARLMEGAQE
410
VSCSAFGDAM IARM
Length:414
Mass (Da):45,212
Last modified:January 4, 2005 - v1
Checksum:iD2B91F1DC84F5807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06557.1.
RefSeqiWP_011236290.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI06557; CAI06557; ebA829.
KEGGieba:ebA829.
PATRICi20966909. VBIAroAro98752_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06557.1.
RefSeqiWP_011236290.1. NC_006513.1.

3D structure databases

ProteinModelPortaliQ5P804.
SMRiQ5P804. Positions 4-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi76114.ebA829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI06557; CAI06557; ebA829.
KEGGieba:ebA829.
PATRICi20966909. VBIAroAro98752_0428.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciAARO76114:GJTA-441-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1Imported.

Entry informationi

Entry nameiQ5P804_AROAE
AccessioniPrimary (citable) accession number: Q5P804
Entry historyi
Integrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 22, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.