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Q5P804

- Q5P804_AROAE

UniProt

Q5P804 - Q5P804_AROAE

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAARO76114:GJTA-441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
ORF Names:ebA829Imported
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))Imported
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA829.

Structurei

3D structure databases

ProteinModelPortaliQ5P804.
SMRiQ5P804. Positions 4-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRYAIDND.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P804-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTSHITVPT GGQKIIPGQP IPDNPIIPFI EGDGIGVDIT PVMIKVIDAA
60 70 80 90 100
VAKAYGGKRK IHWMEVYAGE KSTQVYGPDE WLSKETLDAL KEYSVSIKGP
110 120 130 140 150
MTTPVGGGIR SLNVALRQEL DLYQCVRPIQ YFKGVPSPLK NPELTNMVIF
160 170 180 190 200
RENTEDIYAG IEWQADSEQA RKVIAFLQNE MGVRKIRFPA TSGIGIKPVS
210 220 230 240 250
VEGTQRLVRA ALKYVIDNDR KSLTIVHKGN IMKFTEGLFR DVAYELAQKE
260 270 280 290 300
FGAQPIDGGP WCKFKNPNTG REIVVKDSIA DAFLQQILLR PAEYDVIATT
310 320 330 340 350
NLNGDYISDA LAAQVGGIGI APGANISDQY ACFEATHGTA PKYAGLDKVN
360 370 380 390 400
PGSLILSAEM MLRFMKWTEA ADLVIKGMEA AIGDKVVTYD FARLMEGAQE
410
VSCSAFGDAM IARM
Length:414
Mass (Da):45,212
Last modified:January 4, 2005 - v1
Checksum:iD2B91F1DC84F5807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06557.1.
RefSeqiYP_157458.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI06557; CAI06557; ebA829.
GeneIDi3181703.
KEGGieba:ebA829.
PATRICi20966909. VBIAroAro98752_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06557.1 .
RefSeqi YP_157458.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5P804.
SMRi Q5P804. Positions 4-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI06557 ; CAI06557 ; ebA829 .
GeneIDi 3181703.
KEGGi eba:ebA829.
PATRICi 20966909. VBIAroAro98752_0428.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi RYAIDND.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci AARO76114:GJTA-441-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1Imported.

Entry informationi

Entry nameiQ5P804_AROAE
AccessioniPrimary (citable) accession number: Q5P804
Entry historyi
Integrated into UniProtKB/TrEMBL: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3