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Q5P804

- Q5P804_AROAE

UniProt

Q5P804 - Q5P804_AROAE

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciAARO76114:GJTA-441-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    ORF Names:ebA829Imported
    OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))Imported
    Taxonomic identifieri76114 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
    ProteomesiUP000006552: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi76114.ebA829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5P804.
    SMRiQ5P804. Positions 4-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiRYAIDND.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5P804-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSHITVPT GGQKIIPGQP IPDNPIIPFI EGDGIGVDIT PVMIKVIDAA    50
    VAKAYGGKRK IHWMEVYAGE KSTQVYGPDE WLSKETLDAL KEYSVSIKGP 100
    MTTPVGGGIR SLNVALRQEL DLYQCVRPIQ YFKGVPSPLK NPELTNMVIF 150
    RENTEDIYAG IEWQADSEQA RKVIAFLQNE MGVRKIRFPA TSGIGIKPVS 200
    VEGTQRLVRA ALKYVIDNDR KSLTIVHKGN IMKFTEGLFR DVAYELAQKE 250
    FGAQPIDGGP WCKFKNPNTG REIVVKDSIA DAFLQQILLR PAEYDVIATT 300
    NLNGDYISDA LAAQVGGIGI APGANISDQY ACFEATHGTA PKYAGLDKVN 350
    PGSLILSAEM MLRFMKWTEA ADLVIKGMEA AIGDKVVTYD FARLMEGAQE 400
    VSCSAFGDAM IARM 414
    Length:414
    Mass (Da):45,212
    Last modified:January 4, 2005 - v1
    Checksum:iD2B91F1DC84F5807
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI06557.1.
    RefSeqiYP_157458.1. NC_006513.1.

    Genome annotation databases

    EnsemblBacteriaiCAI06557; CAI06557; ebA829.
    GeneIDi3181703.
    KEGGieba:ebA829.
    PATRICi20966909. VBIAroAro98752_0428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI06557.1 .
    RefSeqi YP_157458.1. NC_006513.1.

    3D structure databases

    ProteinModelPortali Q5P804.
    SMRi Q5P804. Positions 4-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 76114.ebA829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI06557 ; CAI06557 ; ebA829 .
    GeneIDi 3181703.
    KEGGi eba:ebA829.
    PATRICi 20966909. VBIAroAro98752_0428.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi RYAIDND.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci AARO76114:GJTA-441-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
      Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
      Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EbN1Imported.

    Entry informationi

    Entry nameiQ5P804_AROAE
    AccessioniPrimary (citable) accession number: Q5P804
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3