Reviewed,
UniProtKB/Swiss-Prot Q5P7Z9 (DUT_AZOSE)
Last modified
February 9, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Deoxyuridine 5'-triphosphate nucleotidohydrolase Short name=dUTPase EC=3.6.1.23 Alternative name(s): dUTP pyrophosphatase | ||||||
| Gene names |
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| Organism | Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 76114 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum |
Protein attributes
| Sequence length | 149 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 |
| Catalytic activity | dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 |
| Cofactor | Magnesium By similarity. HAMAP MF_00116 |
| Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116 |
| Sequence similarities | Belongs to the dUTPase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | dUTP metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 149 | 149 | Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116 | PRO_0000231397 | |||||
Regions | |||||||||
| Region | 68 – 70 | 3 | Substrate binding By similarity | ||||||
| Region | 85 – 87 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 81 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR555306 Genomic DNA. Translation: CAI06562.1. |
| RefSeq | YP_157463.1. |
3D structure databases | |
| SMR | Q5P7Z9. Positions 1-133. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5P7Z9. |
Genome annotation databases | |
| GeneID | 3179948. |
| GenomeReviews | Gene locus AZOSEA04400 in contig CR555306_GR. |
| KEGG | eba:ebA837. |
| NMPDR | fig|76114.4.peg.1273. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0756. |
| HOGENOM | HBG436079. |
| OMA | HVADPSL. |
Enzyme and pathway databases | |
| BioCyc | ASP76114:EBA837-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00116. dUTPase_bact. [Tree] |
| InterPro | IPR008180. DeoxyUTP_pyroPase_dom. IPR008181. dUTP_pyrophosphatase_subfam_1. [Graphical view] |
| Pfam | PF00692. dUTPase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00576. dut. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DUT_AZOSE | ||||||||
| Accession | Primary (citable) accession number: Q5P7Z9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


