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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37S-adenosyl-L-methionineUniRule annotation1
Binding sitei56S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei77S-adenosyl-L-methionineUniRule annotation1
Binding sitei121S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:AZOSEA04960
ORF Names:ebA914
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
Proteomesi
  • UP000006552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002417011 – 234Ubiquinone biosynthesis O-methyltransferaseAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA914.

Structurei

3D structure databases

ProteinModelPortaliQ5P7U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiVNYMLAC.
OrthoDBiPOG091H064Z.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5P7U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMNADPAEL QKFSELAHRW WDTTSEFKPL HEINPLRLDW IDRNAGLAGK
60 70 80 90 100
RVLDIGCGGG ILSESMAAAG AHVTGIDLSE KALGVARLHL FESGQKVDYH
110 120 130 140 150
HASAEEFAAQ HAGEFDIVTC MEMLEHVPDP ASTVAACAQL VRPGGQVFFS
160 170 180 190 200
TINRNFKAYL FAVLGAEYIL KLLPRGTHDY VKFIRPSELA RYCRQAGLET
210 220 230
AELLGMSYNP LTQVYSLGND TDVNYLVHAK QAVS
Length:234
Mass (Da):25,777
Last modified:January 4, 2005 - v1
Checksum:i5F0996CADF31B7BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06618.1.
RefSeqiWP_011236348.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI06618; CAI06618; ebA914.
KEGGieba:ebA914.
PATRICi20967047. VBIAroAro98752_0495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06618.1.
RefSeqiWP_011236348.1. NC_006513.1.

3D structure databases

ProteinModelPortaliQ5P7U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi76114.ebA914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI06618; CAI06618; ebA914.
KEGGieba:ebA914.
PATRICi20967047. VBIAroAro98752_0495.

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OMAiVNYMLAC.
OrthoDBiPOG091H064Z.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIG_AROAE
AccessioniPrimary (citable) accession number: Q5P7U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.