Reviewed, UniProtKB/Swiss-Prot Q5P7T9 (ARGC_AZOSE)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	AZOSEA05000
ORF Names:	ebA935

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112376
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5P7T9-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 492489C32443A2D3	FASTA	342	37,072
	10 20 30 40 50 60 MIKIGVVGGT GYTGVELLRL LARHPEANLV AITSRGDAGM PVCDMFPSLR GRVDLRFVTP 70 80 90 100 110 120 QDAALDRCDV VFFATPNGIA MQQARELVDA GVRLIDLAAD FRIRDVGEWE KWYGMKHASP 130 140 150 160 170 180 ELVAEAVYGL PERNRERIRS ARILANPGCY PTAVQLGFLP LVEAGVVDLS HLIADVKSGV 190 200 210 220 230 240 SGAGRKAEVH TLFAEAADNF KAYAVAGHRH LPEIRQGLEA MAGQGVGLTF VPHLTPIIRG 250 260 270 280 290 300 IHATLYARLS TDVNVQKLFE ERYQNELFVD VLPAGSHPET RSVRASNLCR VAVHRPQGSD 310 320 330 340 VVVVLSVIDN LVKGAAGQAV QCMNIMFELD ESLGLDILPV SP

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI06622.1.
RefSeq	YP_157523.1.
3D structure databases
SMR	Q5P7T9. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P7T9.
Genome annotation databases
GeneID	3181196.
GenomeReviews	Gene locus AZOSEA05000 in contig CR555306_GR.
KEGG	eba:ebA935.
NMPDR	fig|76114.4.peg.1433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	ASP76114:EBA935-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AZOSE

Accession

Primary (citable) accession number: Q5P7T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	January 4, 2005
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)