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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441UniRule annotation
Active sitei578 – 5781UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciAARO76114:GJTA-627-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:AZOSEA06140
ORF Names:ebA1167
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 916916Phosphoenolpyruvate carboxylasePRO_0000166579Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA1167.

Structurei

3D structure databases

ProteinModelPortaliQ5P7H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P7H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDKDAPLR EDIRLLGRVL GDTVRDQHGE AAFALIERIR QTSVRFRRDD
60 70 80 90 100
DNAARLELEG ILDALSREQT IEVVRAFSYF SHLSNIAEDQ HHIRRSRAHL
110 120 130 140 150
IAGSAPREGS VAHALVRALA SGLPPARLAA FFDTALISPV LTAHPTEVQR
160 170 180 190 200
KSILNCETDI AHLLDARDRM TLTPEERQES DEALRRTVLT LWQTRMLRPA
210 220 230 240 250
KLSVVDEVAN GLSYFDATFL RELPHLYANL EDQLVSRDPA LAGLELPAFL
260 270 280 290 300
QVGSWIGGDR DGNPFVTADV LERTLAMQAG AVLGFYLDEL HALGARLSLA
310 320 330 340 350
LGLVTASDAL LALAARSPDH SPHRNDEPYR RAISGIYARL AATHHALLGT
360 370 380 390 400
EPPRHPVAVA EPYAAVAELA DDLDVIHRSL VANGSAALAR GQLRRLRRAV
410 420 430 440 450
RVFGFHLAPI DLRQNSEVHE RVVAELLATA RTGTDYATLD EAARVELLIE
460 470 480 490 500
ELATPRPLAS PHVRYSDETE GELAIFRTAR AAHRRYGGPA IPNCIISKTD
510 520 530 540 550
DVSDLLELAL LLKEAGLLRP HERALDVNIV PLFETIEDLA NAPSVMDRLF
560 570 580 590 600
ALPGYMNLLA ASRDRTHEVM LGYSDSNKDG GFLTSGWALY KAEIGLIEVF
610 620 630 640 650
ARHGIRLRLF HGRGGSVGRG GGPSYEAILA QPGGAVQGQI RLTEQGEVIA
660 670 680 690 700
AKYGNPEVGR RNLEVIVAAT LEASLLADRA PAPRVEFLDT MQALSDVAFA
710 720 730 740 750
AYRGLVYDTE GFERYFWEST VISEIAELNI GSRPASRKKG TRIEDLRAIP
760 770 780 790 800
WVFSWSQCRL MLPGWFGFGS AVKTWLAAHA DDGIARLQAM HREWSFFAAL
810 820 830 840 850
LSNMDMVLAK TDLAIASRYA GLVKDVNLRD AIFERIRNEW HDTVDALLAI
860 870 880 890 900
TGQRELLDGN PLLKRSIRNR FPYLDPLNHV QVELLRRHRE THDDARIRLG
910
IHISINGIAA GLRNSG
Length:916
Mass (Da):101,239
Last modified:August 30, 2005 - v2
Checksum:i4A45C86CF16B69EC
GO

Sequence cautioni

The sequence CAI06736.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06736.1. Different initiation.
RefSeqiYP_157637.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI06736; CAI06736; ebA1167.
GeneIDi3179678.
KEGGieba:ebA1167.
PATRICi20967315. VBIAroAro98752_0624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR555306 Genomic DNA. Translation: CAI06736.1. Different initiation.
RefSeqiYP_157637.1. NC_006513.1.

3D structure databases

ProteinModelPortaliQ5P7H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi76114.ebA1167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI06736; CAI06736; ebA1167.
GeneIDi3179678.
KEGGieba:ebA1167.
PATRICi20967315. VBIAroAro98752_0624.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciAARO76114:GJTA-627-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiCAPP_AROAE
AccessioniPrimary (citable) accession number: Q5P7H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: January 7, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.