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Q5P7H3 (ARLY_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:AZOSEA06160
ORF Names:ebA1170
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Argininosuccinate lyase HAMAP MF_00006
PRO_0000240711

Sequences

Sequence LengthMass (Da)Tools
Q5P7H3 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 8C8360BE02A9D3F5

FASTA46551,211
        10         20         30         40         50         60 
MTDTSSSQPA KAWSGRFSEP VSDLVKRYTA SVSFDQRMAQ QDIRGSLAHA KMLARQGIIG 

        70         80         90        100        110        120 
ATDLADIERG MVQIRGEIER GEFAWNLDDE DVHLNIEKRL TALVGNPGKR LHTGRSRNDQ 

       130        140        150        160        170        180 
VATDIRLWLR DAIDRILALI GEFQKNLLDV AEANAATPMP GFTHLQVAQP VTFGHHLMAY 

       190        200        210        220        230        240 
FEMSRRDAER FTDCRKRVNR LPLGAAALAG TSYPIDREFV ARELGFDEVC HNSLDAVSDR 

       250        260        270        280        290        300 
DFAIEFCAAS ALLMTHLSRL SEELILWMSP RVGFIDLADR FCTGSSIMPQ KKNPDVPELV 

       310        320        330        340        350        360 
RGKTGRVNGS LIALLTLMKG QPLAYNKDNQ EDKEPLFDTA DTVIDTLRIY ADMITGIRVK 

       370        380        390        400        410        420 
ADAMRDALKQ GYATATDLAD YLVKKGLPFR DAHEAVALAV RAAEAKGCDL PDFSLDELRA 

       430        440        450        460 
FSPLVGEDVF AVLTVEGSLA SRAHVGGTAP EQVRAAITRA RGKNA

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI06738.1.
RefSeqYP_157639.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P7H3.
SMRQ5P7H3. Positions 23-463.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P7H3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3181072.
GenomeReviewsGene locus AZOSEA06160 in contig CR555306_GR.
KEGGeba:ebA1170.
NMPDRfig|76114.4.peg.1735.
PATRIC20967321. VBIAroAro98752_0627.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycASP76114:EBA1170-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_AROAE
AccessionPrimary (citable) accession number: Q5P7H3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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