Reviewed, UniProtKB/Swiss-Prot Q5P796 (HIS3_AZOSE)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-AMP cyclohydrolase
      Short name=PRA-CH
    EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	AZOSEA06920
ORF Names:	ebB39

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000229808

Sequences

	Sequence		Length	Mass (Da)
	Q5P796-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: B63EF7E663D922B0	FASTA	133	15,343
	10 20 30 40 50 60 MSRPNSVRWL NEVQWDDQGL VPVIAQEAAS GDVLMFAWMN REALQRTAET GEAIYWSRSR 70 80 90 100 110 120 RRLWHKGEES GHIQKVLEIR LDCDSDVVLL KIEQIGGIAC HTGRHSCFFQ RYLADGSWET 130 VDPVVKDPKD IYK

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI06815.1.
RefSeq	YP_157716.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3179535.
GenomeReviews	Gene locus AZOSEA06920 in contig CR555306_GR.
KEGG	eba:ebB39.
NMPDR	fig|76114.4.peg.2005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P796.
OMA	Q5P796. LWLKGES.
Enzyme and pathway databases
BioCyc	ASP76114:EBB39-MON.
Family and domain databases
HAMAP	MF_01021. [Tree]
InterPro	IPR002496. PRA_CycHdrlase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_cyclohydro. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_AZOSE

Accession

Primary (citable) accession number: Q5P796

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)