ID   HIS4_AZOSE              Reviewed;         249 AA.
AC   Q5P794;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=AZOSEA06940; ORFNames=ebA1293;
OS   Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Aromatoleum.
OX   NCBI_TaxID=76114;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA   Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA   Reinhardt R.;
RT   "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT   bacterium, strain EbN1.";
RL   Arch. Microbiol. 183:27-36(2005).
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CR555306; CAI06817.1; -; Genomic_DNA.
DR   RefSeq; YP_157718.1; -.
DR   GeneID; 3179641; -.
DR   GenomeReviews; CR555306_GR; AZOSEA06940.
DR   KEGG; eba:ebA1293; -.
DR   NMPDR; fig|76114.4.peg.2007; -.
DR   HOGENOM; Q5P794; -.
DR   OMA; Q5P794; VATRGWL.
DR   BioCyc; ASP76114:EBA1293-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    249       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000229041.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    131    131       Proton donor (By similarity).
SQ   SEQUENCE   249 AA;  26145 MW;  899CB253115FE6A2 CRC64;
     MLLIPAIDLK DGHCVRLKQG EMDDATVFSE DPAAMARHWI EQGARRLHLV DLNGAFAGKP
     KNGAAIRSIV DEVGDDIPVQ LGGGVRDLDT IEHYLDNGIS YIIIGTAAVK NPGFLHDACG
     AFPGHIIVGL DARDGKVAVD GWSKMTGHDV VDLAKKYEDY GVEAVIYTDI GRDGMLSGVN
     VEATVRLAQA LRIPVIASGG IASIADIDAL CAVEAEGIMG AITGRAIYEG ALDFAVAQAR
     ADELNGGEG
//