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Q5P790

- HISX_AROAE

UniProt

Q5P790 - HISX_AROAE

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Protein
Histidinol dehydrogenase
Gene
hisD, AZOSEA06980, ebA1299
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371NAD By similarity
Binding sitei198 – 1981NAD By similarity
Binding sitei221 – 2211NAD By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi266 – 2661Zinc By similarity
Binding sitei266 – 2661Substrate By similarity
Metal bindingi269 – 2691Zinc By similarity
Binding sitei269 – 2691Substrate By similarity
Active sitei334 – 3341Proton acceptor By similarity
Active sitei335 – 3351Proton acceptor By similarity
Binding sitei335 – 3351Substrate By similarity
Metal bindingi368 – 3681Zinc By similarity
Binding sitei368 – 3681Substrate By similarity
Binding sitei422 – 4221Substrate By similarity
Metal bindingi427 – 4271Zinc By similarity
Binding sitei427 – 4271Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciAARO76114:GJTA-714-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:AZOSEA06980
ORF Names:ebA1299
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Histidinol dehydrogenaseUniRule annotation
PRO_0000135718Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA1299.

Structurei

3D structure databases

ProteinModelPortaliQ5P790.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P790-1 [UniParc]FASTAAdd to Basket

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MTAPAAAIRR LDAREPEFLA TLDALLAFEG GADARIDAAV SEILRAVRTT    50
GDAAVLEYTR RFDHLDVKSM VQLELSKSEL KAALDSLTVE QREALRVAAD 100
RVRVYHERQR AESWDYVEAD GTRLGQKVTP LDRVGLYVPG GRASYPSSVL 150
MNAIPAKVAG VGELIMVVPT PNGEKNPLVL AAAAITGVDR VFTIGGAQAV 200
AALAYGTQTL PQVDKIVGPG NAYVAEAKRR VFGTVGIDMV AGPSEVLIIS 250
DGSGQAGWVA MDLFAQAEHD ELAQSILLCT DAGFIDAVAA SIERLLPSMP 300
RRETIAASLA NRGALIHVDS LEQACAIANR IAPEHLELSL DDAEPWIGRI 350
RHAGAIFVGH WSVEALGDYC AGPNHVLPTM RSARFSSPLG VYDFQKRTSI 400
VQISEAGAQT LGRVASILAR GEGLQAHARS AEMRLHDR 438
Length:438
Mass (Da):46,793
Last modified:January 4, 2005 - v1
Checksum:i4416060B3F732E8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI06821.1.
RefSeqiYP_157722.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI06821; CAI06821; ebA1299.
GeneIDi3179686.
KEGGieba:ebA1299.
PATRICi20967489. VBIAroAro98752_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI06821.1 .
RefSeqi YP_157722.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5P790.
ModBasei Search...

Protein-protein interaction databases

STRINGi 76114.ebA1299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI06821 ; CAI06821 ; ebA1299 .
GeneIDi 3179686.
KEGGi eba:ebA1299.
PATRICi 20967489. VBIAroAro98752_0708.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci AARO76114:GJTA-714-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiHISX_AROAE
AccessioniPrimary (citable) accession number: Q5P790
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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