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Q5P790

- HISX_AROAE

UniProt

Q5P790 - HISX_AROAE

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371NADUniRule annotation
    Binding sitei198 – 1981NADUniRule annotation
    Binding sitei221 – 2211NADUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Metal bindingi266 – 2661ZincUniRule annotation
    Binding sitei266 – 2661SubstrateUniRule annotation
    Metal bindingi269 – 2691ZincUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Binding sitei335 – 3351SubstrateUniRule annotation
    Metal bindingi368 – 3681ZincUniRule annotation
    Binding sitei368 – 3681SubstrateUniRule annotation
    Binding sitei422 – 4221SubstrateUniRule annotation
    Metal bindingi427 – 4271ZincUniRule annotation
    Binding sitei427 – 4271SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciAARO76114:GJTA-714-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:AZOSEA06980
    ORF Names:ebA1299
    OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
    Taxonomic identifieri76114 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
    ProteomesiUP000006552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Histidinol dehydrogenasePRO_0000135718Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi76114.ebA1299.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5P790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiCAIANRI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5P790-1 [UniParc]FASTAAdd to Basket

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    MTAPAAAIRR LDAREPEFLA TLDALLAFEG GADARIDAAV SEILRAVRTT    50
    GDAAVLEYTR RFDHLDVKSM VQLELSKSEL KAALDSLTVE QREALRVAAD 100
    RVRVYHERQR AESWDYVEAD GTRLGQKVTP LDRVGLYVPG GRASYPSSVL 150
    MNAIPAKVAG VGELIMVVPT PNGEKNPLVL AAAAITGVDR VFTIGGAQAV 200
    AALAYGTQTL PQVDKIVGPG NAYVAEAKRR VFGTVGIDMV AGPSEVLIIS 250
    DGSGQAGWVA MDLFAQAEHD ELAQSILLCT DAGFIDAVAA SIERLLPSMP 300
    RRETIAASLA NRGALIHVDS LEQACAIANR IAPEHLELSL DDAEPWIGRI 350
    RHAGAIFVGH WSVEALGDYC AGPNHVLPTM RSARFSSPLG VYDFQKRTSI 400
    VQISEAGAQT LGRVASILAR GEGLQAHARS AEMRLHDR 438
    Length:438
    Mass (Da):46,793
    Last modified:January 4, 2005 - v1
    Checksum:i4416060B3F732E8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI06821.1.
    RefSeqiYP_157722.1. NC_006513.1.

    Genome annotation databases

    EnsemblBacteriaiCAI06821; CAI06821; ebA1299.
    GeneIDi3179686.
    KEGGieba:ebA1299.
    PATRICi20967489. VBIAroAro98752_0708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI06821.1 .
    RefSeqi YP_157722.1. NC_006513.1.

    3D structure databases

    ProteinModelPortali Q5P790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 76114.ebA1299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI06821 ; CAI06821 ; ebA1299 .
    GeneIDi 3179686.
    KEGGi eba:ebA1299.
    PATRICi 20967489. VBIAroAro98752_0708.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi CAIANRI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci AARO76114:GJTA-714-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
      Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
      Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EbN1.

    Entry informationi

    Entry nameiHISX_AROAE
    AccessioniPrimary (citable) accession number: Q5P790
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3