Reviewed, UniProtKB/Swiss-Prot Q5P722 (PTH_AZOSE)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	AZOSEA07660
ORF Names:	ebA1411

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187682

Sequences

	Sequence		Length	Mass (Da)
	Q5P722-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 6A6FF5D927F02276	FASTA	196	21,577
	10 20 30 40 50 60 MSAAAPRLVV GLGNPGAEYT ETRHNAGFRF CERLADKLGV RFSHESRFHG FVANARDAGV 70 80 90 100 110 120 WLLMPQTYMN RSGQAVGALA RFYRIAPAEI LVVHDELDIP PGQLRLKFGG GLGGHNGLKD 130 140 150 160 170 180 TSAHLATNDY WRLRIGIGHP GDRNEVVNYV LKPARREEQG QIDEALDRAL AAWPMIARGE 190 WNAATTRLNA RPAALK

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI06889.1.
RefSeq	YP_157790.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P722.
Genome annotation databases
GeneID	3182908.
GenomeReviews	Gene locus AZOSEA07660 in contig CR555306_GR.
KEGG	eba:ebA1411.
NMPDR	fig|76114.4.peg.2257.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P722.
OMA	IKFKTGG.
Enzyme and pathway databases
BioCyc	ASP76114:EBA1411-MON.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. False negative. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_AZOSE

Accession

Primary (citable) accession number: Q5P722

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	January 4, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)