Q5P6Z4 (MURD_AROAE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 56.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UDP-N-acetylmuramoylalanine--D-glutamate ligase EC=6.3.2.9 Alternative name(s): D-glutamic acid-adding enzyme UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | ||||||
| Gene names |
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| Organism | Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 76114 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 |
| Catalytic activity | ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00639. |
| Sequence similarities | Belongs to the MurCDEF family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell divisionInferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organizationInferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW regulation of cell shapeInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramoylalanine-D-glutamate ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 | PRO_0000108958 | |||||
Regions | |||||||||
| Nucleotide binding | 122 – 128 | 7 | ATP Potential | ||||||
Sequences
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References
| [1] | "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EbN1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR555306 Genomic DNA. Translation: CAI06917.1. |
| RefSeq | YP_157818.1. NC_006513.1. |
3D structure databases | |
| ProteinModelPortal | Q5P6Z4. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5P6Z4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3182700. |
| GenomeReviews | Gene locus AZOSEA07940 in contig CR555306_GR. |
| KEGG | eba:ebA1447. |
| NMPDR | fig|76114.4.peg.2396. |
| PATRIC | 20967677. VBIAroAro98752_0799. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0771. |
| HOGENOM | HBG750024. |
| OMA | LERHKTL. |
| ProtClustDB | PRK02006. |
Enzyme and pathway databases | |
| BioCyc | ASP76114:EBA1447-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00639. MurD. [Tree] |
| InterPro | IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR016040. NAD(P)-bd_dom. IPR005762. UDP-N-AcMur-Glu_ligase. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K01925. |
| PANTHER | PTHR23135:SF2. PTHR23135:SF2. 1 hit. |
| Pfam | PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| SUPFAM | SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit. |
| TIGRFAMs | TIGR01087. MurD. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURD_AROAE | ||||||||
| Accession | Primary (citable) accession number: Q5P6Z4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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