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Q5P6Z4 (MURD_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:AZOSEA07940
ORF Names:ebA1447
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_0000108958

Regions

Nucleotide binding122 – 1287ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5P6Z4 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 2877A8A56F66AD8D

FASTA46648,375
        10         20         30         40         50         60 
MSALTGKHVL VLGLGESGLA MARWCALRGA RLRVADSRQT PPGLDTLRAD APLAEIVVGN 

        70         80         90        100        110        120 
FGAEVLSGID LVALSPGVDP RIGIAAEARH RGLPLTGEMS LLAQALDELG VRAQTRILAI 

       130        140        150        160        170        180 
TGTNGKTTTT ALTAALAQAA GLDAVAAGNI SPAALDVLMD RLAQGAPLPE CWVLELSSFQ 

       190        200        210        220        230        240 
IETMHALDPE AATVLNVTDD HLDRYAGLDE YAATKAAIFE GRGVQVLNRD DARVAAMALP 

       250        260        270        280        290        300 
GRSLIRFGAS APAATDDYGL VEVAGAAWLV RGRERLLALA DLPLAGRHNA ANTLAALALC 

       310        320        330        340        350        360 
EGGLGIAPQR LTGAVVAFRG LPHRVELVAE RSDGVRFYDD SKGTNVGATV AALDGMDCPV 

       370        380        390        400        410        420 
VLIAGGDGKG QDFSPLREAV VRRARAVVLI GRDAPRIESA LQGSAVALEH APDLDAAVVR 

       430        440        450        460 
ASEQAQPGDA VLLSPACASL DMFRNYAHRA EVFIAAARRL PEVRAS

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI06917.1.
RefSeqYP_157818.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P6Z4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P6Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3182700.
GenomeReviewsGene locus AZOSEA07940 in contig CR555306_GR.
KEGGeba:ebA1447.
NMPDRfig|76114.4.peg.2396.
PATRIC20967677. VBIAroAro98752_0799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMALERHKTL.
ProtClustDBPRK02006.

Enzyme and pathway databases

BioCycASP76114:EBA1447-MONOMER.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_AROAE
AccessionPrimary (citable) accession number: Q5P6Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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