Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5P6Z3 (MRAY_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:AZOSEA07950
ORF Names:ebA1448
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108773

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane339 – 35921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5P6Z3 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 8558EAF5E68A54CF

FASTA36238,992
        10         20         30         40         50         60 
MLLEFALWLG QDIRAFNVFG YITLRTVMAA MTALLISFAC GPAVIRWLAA KKIGQAVRDD 

        70         80         90        100        110        120 
GPKSHLTKAG TPTMGGALII IAIAVTTLLW GDLRNQYVWV TLLVTLGFGA VGWVDDWRKV 

       130        140        150        160        170        180 
VHRDPKGLAS RWKYLWTSLI ALAAALFLGL TANEPAQTEL IVPFFKAVSY PLGMLGFVAL 

       190        200        210        220        230        240 
SYFVINGTSH SVNLTDGLDG LAIMPTVMVA GALAIFAYVA GHAGFSKYLG VPYIAGAGEL 

       250        260        270        280        290        300 
AVFCGALAGA GLGFLWFNAY PAEVFMGDVG ALALGAALGT VAVVVRQEIV LFIMGGLFVA 

       310        320        330        340        350        360 
ETLSVMVQVL YFKASGGKRI FRMAPLHHHY ELGGWKETQV VVRFWIITIM LVLFGLSTLK 


LR

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI06918.1.
RefSeqYP_157819.1. NC_006513.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P6Z3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3181217.
GenomeReviewsGene locus AZOSEA07950 in contig CR555306_GR.
KEGGeba:ebA1448.
NMPDRfig|76114.4.peg.2397.
PATRIC20967679. VBIAroAro98752_0800.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycASP76114:EBA1448-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_AROAE
AccessionPrimary (citable) accession number: Q5P6Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents