Q5P6K4 (UPPP_AROAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	upk
Ordered Locus Names:	AZOSEA09320
ORF Names:	ebA1726

Organism

Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum › Aromatoleum aromaticum

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151084
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	246 – 266	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5P6K4 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 399202A419562630	FASTA	274	30,013
	10 20 30 40 50 60 MDLPLFVIAL ILGIVEGLTE FLPISSTGHL IIIGDLLGYN DATSKVFKIV IQFAAILAVC 70 80 90 100 110 120 WDYRERLARV AAGVGSEPAA QRFVGLLFIG FLPAAVLGLM FHSTIKSLLF NPLTVATALV 130 140 150 160 170 180 VGGVLILWLE RRAYHPRINA VDEMRWADAL KVGFAQAAAM IPGTSRSGAT ILGGLVFGLS 190 200 210 220 230 240 RKAAAEFSFF LSIPTMFAAT VYDLYKNRDL LHMGDLPVFA IGFVASFFAA MFAVKAFIRF 250 260 270 ISNHTFIAFA WYRIVFGLVV LATWQLELVE WSEP

References

[1]

"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: EbN1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI07057.1.
RefSeq	YP_157958.1. NC_006513.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	76114.ebA1726.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI07057; CAI07057; ebA1726.
GeneID	3183038.
KEGG	eba:ebA1726.
PATRIC	20967973. VBIAroAro98752_0947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	AARO76114:GJTA-951-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_AROAE

Accession

Primary (citable) accession number: Q5P6K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program