ID   AROE_AZOSE              Reviewed;         279 AA.
AC   Q5P6J9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=AZOSEA09370; ORFNames=ebA1735;
OS   Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Aromatoleum.
OX   NCBI_TaxID=76114;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA   Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA   Reinhardt R.;
RT   "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT   bacterium, strain EbN1.";
RL   Arch. Microbiol. 183:27-36(2005).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CR555306; CAI07062.1; -; Genomic_DNA.
DR   RefSeq; YP_157963.1; -.
DR   GeneID; 3181023; -.
DR   GenomeReviews; CR555306_GR; AZOSEA09370.
DR   KEGG; eba:ebA1735; -.
DR   NMPDR; fig|76114.4.peg.378; -.
DR   HOGENOM; Q5P6J9; -.
DR   OMA; Q5P6J9; LEGANIT.
DR   BioCyc; ASP76114:EBA1735-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    279       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021257.
FT   NP_BIND     128    132       NADP (By similarity).
FT   ACT_SITE     67     67       Proton acceptor (Potential).
SQ   SEQUENCE   279 AA;  29287 MW;  B5F011E2F3666C14 CRC64;
     MTIDRYAVIG NPISHSRSPA IHAEFARQTG QQLSYEALLA PLDGFRDAVE RFRRAGGRGM
     NVTVPFKLEA FALTDRCAPR ASAAGAVNTL AFGPDGIFGD NTDGAGLIRD IVHNLDRPLE
     RQRVLLLGAG GAARGVLLPL LAARPASLTL ANRSVDKAHA LAAAFRSHAP DVALDACSFV
     DLAGRVFDVV INATAASLAN EAPQLPPGLY AANALAYDMM YGCGDTPFLA AARSDGATQR
     ADGLGMLVEQ AAESFLLWRG VRPDTAAVLA ALRRQLDGG
//