Reviewed, UniProtKB/Swiss-Prot Q5P6J9 (AROE_AZOSE)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	AZOSEA09370
ORF Names:	ebA1735

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Shikimate dehydrogenase		PRO_1000021257
Regions
	Nucleotide binding	128 – 132	5	NADP By similarity
Sites
	Active site	67	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5P6J9-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: B5F011E2F3666C14	FASTA	279	29,287
	10 20 30 40 50 60 MTIDRYAVIG NPISHSRSPA IHAEFARQTG QQLSYEALLA PLDGFRDAVE RFRRAGGRGM 70 80 90 100 110 120 NVTVPFKLEA FALTDRCAPR ASAAGAVNTL AFGPDGIFGD NTDGAGLIRD IVHNLDRPLE 130 140 150 160 170 180 RQRVLLLGAG GAARGVLLPL LAARPASLTL ANRSVDKAHA LAAAFRSHAP DVALDACSFV 190 200 210 220 230 240 DLAGRVFDVV INATAASLAN EAPQLPPGLY AANALAYDMM YGCGDTPFLA AARSDGATQR 250 260 270 ADGLGMLVEQ AAESFLLWRG VRPDTAAVLA ALRRQLDGG

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI07062.1.
RefSeq	YP_157963.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3181023.
GenomeReviews	Gene locus AZOSEA09370 in contig CR555306_GR.
KEGG	eba:ebA1735.
NMPDR	fig|76114.4.peg.378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P6J9.
Enzyme and pathway databases
BioCyc	ASP76114:EBA1735-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd. IPR011342. Quinate/shikimate_5-DHase. IPR013708. Shikimate_DHase-bd_N. IPR006151. Shikm_DHase/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_AZOSE

Accession

Primary (citable) accession number: Q5P6J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 4, 2005
Last modified:	November 25, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)