Reviewed, UniProtKB/Swiss-Prot Q5P5P3 (AROB_AZOSE)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	AZOSEA12440
ORF Names:	ebA2256

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm Probable HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000231062

Sequences

	Sequence		Length	Mass (Da)
	Q5P5P3-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: C8B374A6A621A3A8	FASTA	360	38,496
	10 20 30 40 50 60 MRTLNVALGD RAYPIHIGPG VLDNAGLIRP FLRTARVAIV TNDVVGPLYL ARLQRALEAD 70 80 90 100 110 120 GVRVDVVTLP DGESHKNWQT LNLVFDMLLA TRCERSTTLI ALGGGVVGDM AGFAAATYQR 130 140 150 160 170 180 GMPFIQVPTT LLSQVDSSVG GKTAINHPLG KNMIGAFYQP RVVLADTATL DTLPDRELKA 190 200 210 220 230 240 GLAEVIKYGL IRDPALFDWL EAHIERVLAR EPEALAFAIE RSCANKAEVV AADETEQGER 250 260 270 280 290 300 ALLNLGHTFG HAIETGMGYG NWLHGEAVAA GTMMAAELSR RLGWLSAADV ARIEALHVRA 310 320 330 340 350 360 GLPVLGPPLP VATYLELMAN DKKVEEGRLR LVLLRSIGKA VLHAGAAPDV IGASIEARCG

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI07369.1.
RefSeq	YP_158270.1.
3D structure databases
SMR	Q5P5P3. Positions 4-343.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P5P3.
Genome annotation databases
GeneID	3181078.
GenomeReviews	Gene locus AZOSEA12440 in contig CR555306_GR.
KEGG	eba:ebA2256.
NMPDR	fig|76114.4.peg.1621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	APESMDF.
Enzyme and pathway databases
BioCyc	ASP76114:EBA2256-MONOMER.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_AZOSE

Accession

Primary (citable) accession number: Q5P5P3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	January 4, 2005
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)