Reviewed, UniProtKB/Swiss-Prot Q5P5L9 (UBIC_AZOSE)

Names and origin

Protein names

Recommended name:
    Probable chorismate--pyruvate lyase
      Short name=CL
      Short name=CPL
    EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	AZOSEA12680
ORF Names:	ebA2295

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyruvate biosynthetic process Inferred from electronic annotation. Source: HAMAP ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240533
Sites
	Binding site	75	1	Substrate By similarity
	Binding site	113	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5P5L9-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 0A6A316462D55349	FASTA	185	20,742
	10 20 30 40 50 60 MRIRPHSETW LKRPPRPRVP ARLRPWLTDP GSLTARIRSR CSLFSVNVLA QRLAVPHPDE 70 80 90 100 110 120 AALLGLRRGE LAWLREVLLV ADGVPVVFAR SILPRHDVRG AWILFQGLGS RPLGAALFAD 130 140 150 160 170 180 PRIGRKPLAC ACLDRRDARY HRASAAAAPR RLPLALWARR SLFGLRGRTL LVSEVFLPTI LELPT

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR555306 Genomic DNA. Translation: CAI07393.1.
RefSeq	YP_158294.1.
3D structure databases
SMR	Q5P5L9. Positions 6-180.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P5L9.
Genome annotation databases
GeneID	3179501.
GenomeReviews	Gene locus AZOSEA12680 in contig CR555306_GR.
KEGG	eba:ebA2295.
NMPDR	fig|76114.4.peg.1756.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
OMA	QPWVFAR.
Enzyme and pathway databases
BioCyc	ASP76114:EBA2295-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_AZOSE

Accession

Primary (citable) accession number: Q5P5L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	January 4, 2005
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)