Reviewed, UniProtKB/Swiss-Prot Q5P5J5 (NTPA_AZOSE)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:	AZOSEA12920
ORF Names:	c1A234

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178118

Sequences

	Sequence		Length	Mass (Da)
	Q5P5J5-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 0E3D64D88CEA67ED	FASTA	198	20,854
	10 20 30 40 50 60 MTARLVLASN NAKKAVEMTT LLAPLGIEVL PQSAFDIPEA DEPHPTFVEN ALAKARHAAA 70 80 90 100 110 120 LSGLPAVADD SGLCVAALGG APGVQSARFA GEPKSDARNN ALLVERLAGS ADRRAFFYSV 130 140 150 160 170 180 VALVRHADDP RPLIADGEWH GTILYAPRGA NGFGYDPLFF LPELGQTAAE LDAQLKNTLS 190 HRGAAMRHLL ARLSTAPL

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI07417.1.
RefSeq	YP_158318.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3183143.
GenomeReviews	Gene locus AZOSEA12920 in contig CR555306_GR.
KEGG	eba:c1A234.
NMPDR	fig|76114.4.peg.1778.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P5J5.
OMA	Q5P5J5. VYTADWA.
Enzyme and pathway databases
BioCyc	ASP76114:C1A234-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_AZOSE

Accession

Primary (citable) accession number: Q5P5J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	January 4, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)