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Q5P5J5 (NTPA_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:AZOSEA12920
ORF Names:c1A234
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
PRO_0000178118

Regions

Region9 – 146Substrate binding By similarity
Region70 – 712Substrate binding By similarity

Sites

Metal binding411Magnesium or manganese By similarity
Metal binding701Magnesium or manganese By similarity
Binding site1561Substrate By similarity
Binding site1761Substrate By similarity
Binding site1821Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5P5J5 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 0E3D64D88CEA67ED

FASTA19820,854
        10         20         30         40         50         60 
MTARLVLASN NAKKAVEMTT LLAPLGIEVL PQSAFDIPEA DEPHPTFVEN ALAKARHAAA 

        70         80         90        100        110        120 
LSGLPAVADD SGLCVAALGG APGVQSARFA GEPKSDARNN ALLVERLAGS ADRRAFFYSV 

       130        140        150        160        170        180 
VALVRHADDP RPLIADGEWH GTILYAPRGA NGFGYDPLFF LPELGQTAAE LDAQLKNTLS 

       190 
HRGAAMRHLL ARLSTAPL 

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References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR555306 Genomic DNA. Translation: CAI07417.1.
RefSeqYP_158318.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P5J5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P5J5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3183143.
GenomeReviewsGene locus AZOSEA12920 in contig CR555306_GR.
KEGGeba:c1A234.
NMPDRfig|76114.4.peg.1778.
PATRIC20968699. VBIAroAro98752_1310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHBG697237.
OMAGVYTADW.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycASP76114:C1A234-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_AROAE
AccessionPrimary (citable) accession number: Q5P5J5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families