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Q5P4Q4 (DCUP_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:AZOSEA15830
ORF Names:ebA2822
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023872

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3271Substrate By similarity
Site771Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5P4Q4 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 510DD5E5EE413EB8

FASTA35639,300
        10         20         30         40         50         60 
MSRLQNDTFL RALLRQPTDY TPLWMMRQAG RYLPEYCETR RRAGSFLDLC KSPALACEVT 

        70         80         90        100        110        120 
LQPLARYDLD AAILFSDILT VPDAMGLGLY FAEGEGPRFE RPLRDEWEIR NLVAPDPHAE 

       130        140        150        160        170        180 
LQYVMDAVAE IRRALGGSVP LIGFSGSPWT LACYMVEGGS SDDYRRIKTM AYTRPDLLHH 

       190        200        210        220        230        240 
VLRVTADSVV AYLNAQIESG AQAVMVFDSW GGVLSEAAYR EFSLPYLERV VAGLIRERDG 

       250        260        270        280        290        300 
ERIPSIVFTK GGGLWLESIA AIGCDAVGLD WTMDIGRARA LVGDKVALQG NLDPAILFAP 

       310        320        330        340        350 
PETIATEAKR VLDAFGPHPG HVFNLGHGIS QFTPPEAVSV LVDTVHQHSR KLRGGR

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR555306 Genomic DNA. Translation: CAI07708.1.
RefSeqYP_158609.1. NC_006513.1.

3D structure databases

HSSPHSSP built from PDB template 1R3Q based on UniProtKB P06132.
ProteinModelPortalQ5P4Q4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5P4Q4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3179544.
GenomeReviewsGene locus AZOSEA15830 in contig CR555306_GR.
KEGGeba:ebA2822.
NMPDRfig|76114.4.peg.521.
PATRIC20969279. VBIAroAro98752_1596.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycASP76114:EBA2822-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_AROAE
AccessionPrimary (citable) accession number: Q5P4Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 4, 2005
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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