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Q5P3E7 (SYR_AROAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:AZOSEA20420
ORF Names:ebA3614
OrganismAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) [Complete proteome] [HAMAP]
Taxonomic identifier76114 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000241978

Regions

Motif126 – 13611"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5P3E7 [UniParc].

Last modified January 4, 2005. Version 1.
Checksum: 5282E64F1F808A55

FASTA58764,854
        10         20         30         40         50         60 
MSADSKVQLT ALLRAALKSI APELADTPIH LERPKQAGHG DFATNLALQL AKPLRRRPRE 

        70         80         90        100        110        120 
LAELLLAELP RSTLVAATEV AGAGFINFTL AAGAKTAAVG TVLERGAEFG RGARNGTSVQ 

       130        140        150        160        170        180 
LEFVSANPTG PLHVGHGRGA AYGASLAAVL DFAGSDVTRE YYINDAGRQM DILALSTWLR 

       190        200        210        220        230        240 
YLALYGLDIP FPPNAYQGDY VVDMARAMRE GHQDRFAGFT IEQVLEGAPG LPVAERKDDE 

       250        260        270        280        290        300 
AKTQREDHLD MLIANAKRLL GEDYHFVHGF ALNEQLGDGR DDLEEFGVHF DKWFSEKSLF 

       310        320        330        340        350        360 
DTGLVDRAVA ELEKRGHVYL QDGAKWFRST AFGDEKDRVV QRENGLYTYF ASDIAYHLNK 

       370        380        390        400        410        420 
YERGYDRIID IWGADHHGYI PRVKGAIAAL GLPPEKLEVA LVQFAVLYRN GQKASMSTRS 

       430        440        450        460        470        480 
GEFVTLRELR REVGNDACRF FYVLRKSDQH LDFDLDLAKS QSNENPVYYV QYAHARVCSV 

       490        500        510        520        530        540 
LEQWGGEAAE LRAAQLDLLG NERELALCAR LGGFPELIQN AAADHAPHQI AFYLKDLAAE 

       550        560        570        580 
FHSWYNAERM LVDDPALRLA RLALATAVRQ VLATALALLG VSAPQSM 

« Hide

References

[1]"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: EbN1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR555306 Genomic DNA. Translation: CAI08167.1.
RefSeqYP_159068.1. NC_006513.1.

3D structure databases

ProteinModelPortalQ5P3E7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING76114.ebA3614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI08167; CAI08167; ebA3614.
GeneID3181291.
KEGGeba:ebA3614.
PATRIC20970222. VBIAroAro98752_2064.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAPRVKGAI.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycAARO76114:GJTA-2060-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_AROAE
AccessionPrimary (citable) accession number: Q5P3E7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries