Reviewed, UniProtKB/Swiss-Prot Q5P2G1 (TRPC_AZOSE)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	AZOSEA23780
ORF Names:	ebA4201

Organism

Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [Complete proteome] [HAMAP]

Taxonomic identifier

76114 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Rhodocyclales › Rhodocyclaceae › Aromatoleum

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000018434

Sequences

	Sequence		Length	Mass (Da)
	Q5P2G1-1 [UniParc]. Last modified January 4, 2005. Version 1. Checksum: 447E1F786DF148D3	FASTA	262	27,658
	10 20 30 40 50 60 MSDILDKILS VKRDEVAAGS VARPLAQVRA EVEALAAPRN FVGAIRAKIA AGDAAVIAEI 70 80 90 100 110 120 KKASPSKGVI REDFRPAEIA LQYERGGAAC LSVLTDRQFF QGAPAYLQAA RAACSLPVLR 130 140 150 160 170 180 KDFLVDPWQV YEARAMGADA VLLIVAALDL AAMRDMEAVA GSLGMAVLVE AHDAAELDVA 190 200 210 220 230 240 LQLSTPLVGI NNRNLRTFDV SLQTTLDLLA RVPAGRIVVT ESGILAPADV ALMRANAVNA 250 260 FLVGEAFMRV PDPGEGLRSL FG

References

[1]	"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1." Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R. Arch. Microbiol. 183:27-36(2005) [PubMed: 15551059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR555306 Genomic DNA. Translation: CAI08503.1.
RefSeq	YP_159404.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5P2G1.
Genome annotation databases
GeneID	3179740.
GenomeReviews	Gene locus AZOSEA23780 in contig CR555306_GR.
KEGG	eba:ebA4201.
NMPDR	fig|76114.4.peg.1827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5P2G1.
OMA	PLLCKDF.
Enzyme and pathway databases
BioCyc	ASP76114:EBA4201-MON.
Family and domain databases
HAMAP	MF_00134. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GPS_central. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
ProDom	PD001511. IGPS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_AZOSE

Accession

Primary (citable) accession number: Q5P2G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 4, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)