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Q5P252

- SYL_AROAE

UniProt

Q5P252 - SYL_AROAE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei631 – 6311ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAARO76114:GJTA-2513-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:AZOSEA24870
    ORF Names:ebA4386
    OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
    Taxonomic identifieri76114 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
    ProteomesiUP000006552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Leucine--tRNA ligasePRO_1000091289Add
    BLAST

    Proteomic databases

    PRIDEiQ5P252.

    Interactioni

    Protein-protein interaction databases

    STRINGi76114.ebA4386.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5P252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi628 – 6325"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5P252-1 [UniParc]FASTAAdd to Basket

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    MQDKYTPAAV EATAQQHWES TQAFKVAEDA GKPKYYCLSM FPYPSGKLHM    50
    GHVRNYTIGD VLARYHRMRG FNVLQPMGWD AFGMPAENAA IQNNVPPAKW 100
    TYANIDYMKT QLKRLGFALD WSRELATCKP DYYRWEQWLF TRLYQKGLIY 150
    KKLGTVNWDP VDETVLANEQ VIDGRGWRSG ALIEKREIPM YYMKITAYAD 200
    ELLEALDTLT GWPEQVKLMQ KNWIGRSEGV EVHFPYEVST IGASGVLKVF 250
    TTRADTLMGA TYVAVAAEHP LALQAAVNDP ELAAFIEECR HGGVAEADLA 300
    TMEKKGMPTG LRVVHPLTGE HLPVWIANYV LMGYGEGAVM AVPAHDERDF 350
    AFATKYRLPI RMVVRSTRDA YTDTVAPWQD AYAEQGRLVN SGKYDGLHFH 400
    DAIEAIAAEL TAKGLGAKRT QYRLRDWGIS RQRYWGCPIP MIHCADCGDV 450
    PVPDEQLPVV LPEDVAVTGR GSPLAKMPRF YECDCPKCGK PAKRETDTMD 500
    TFVESSWYFL RYASADNGQA MVDERVNYWA PVDQYIGGIE HAILHLLYSR 550
    FFTRAMRDEG LVNVSEPFTN LLTQGMVVAE TYYRDADGGK KQWINPADVE 600
    VERDEKGRIV AAKLTADGAP VVIGGIEKMA KSKNNGVDPQ ALVDQYGADT 650
    ARLFIIFAAP PDQQLEWSDS GVEGAYRFLR RVWSFGHAFV SEFRPQLPAD 700
    RQLDAVQLPE ALAAVRREIH VCLRQANYDF GKHQFNTVVS AAMKILNALE 750
    KAPRDVAAAH AQVAEEGLDI LLRLLAPITP HVAHALWQDC GFTGDVLHAS 800
    WPEPSEDALR QDEIDLVLQV NGKLRGSLRV AAGASNSAIE ALALGSETAQ 850
    KFMEGKPPRK VVVVPGRLVN IVV 873
    Length:873
    Mass (Da):97,432
    Last modified:January 4, 2005 - v1
    Checksum:i17317CB2086C0B1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI08612.1.
    RefSeqiYP_159513.1. NC_006513.1.

    Genome annotation databases

    EnsemblBacteriaiCAI08612; CAI08612; ebA4386.
    GeneIDi3182696.
    KEGGieba:ebA4386.
    PATRICi20971146. VBIAroAro98752_2516.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR555306 Genomic DNA. Translation: CAI08612.1 .
    RefSeqi YP_159513.1. NC_006513.1.

    3D structure databases

    ProteinModelPortali Q5P252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 76114.ebA4386.

    Proteomic databases

    PRIDEi Q5P252.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI08612 ; CAI08612 ; ebA4386 .
    GeneIDi 3182696.
    KEGGi eba:ebA4386.
    PATRICi 20971146. VBIAroAro98752_2516.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AARO76114:GJTA-2513-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
      Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
      Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: EbN1.

    Entry informationi

    Entry nameiSYL_AROAE
    AccessioniPrimary (citable) accession number: Q5P252
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3