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Q5P252

- SYL_AROAE

UniProt

Q5P252 - SYL_AROAE

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Protein

Leucine--tRNA ligase

Gene
leuS, AZOSEA24870, ebA4386
Organism
Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAARO76114:GJTA-2513-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:AZOSEA24870
ORF Names:ebA4386
OrganismiAromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1))
Taxonomic identifieri76114 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaRhodocyclalesRhodocyclaceaeAromatoleum
ProteomesiUP000006552: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Leucine--tRNA ligaseUniRule annotationPRO_1000091289Add
BLAST

Proteomic databases

PRIDEiQ5P252.

Interactioni

Protein-protein interaction databases

STRINGi76114.ebA4386.

Structurei

3D structure databases

ProteinModelPortaliQ5P252.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi628 – 6325"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5P252-1 [UniParc]FASTAAdd to Basket

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MQDKYTPAAV EATAQQHWES TQAFKVAEDA GKPKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VLARYHRMRG FNVLQPMGWD AFGMPAENAA IQNNVPPAKW 100
TYANIDYMKT QLKRLGFALD WSRELATCKP DYYRWEQWLF TRLYQKGLIY 150
KKLGTVNWDP VDETVLANEQ VIDGRGWRSG ALIEKREIPM YYMKITAYAD 200
ELLEALDTLT GWPEQVKLMQ KNWIGRSEGV EVHFPYEVST IGASGVLKVF 250
TTRADTLMGA TYVAVAAEHP LALQAAVNDP ELAAFIEECR HGGVAEADLA 300
TMEKKGMPTG LRVVHPLTGE HLPVWIANYV LMGYGEGAVM AVPAHDERDF 350
AFATKYRLPI RMVVRSTRDA YTDTVAPWQD AYAEQGRLVN SGKYDGLHFH 400
DAIEAIAAEL TAKGLGAKRT QYRLRDWGIS RQRYWGCPIP MIHCADCGDV 450
PVPDEQLPVV LPEDVAVTGR GSPLAKMPRF YECDCPKCGK PAKRETDTMD 500
TFVESSWYFL RYASADNGQA MVDERVNYWA PVDQYIGGIE HAILHLLYSR 550
FFTRAMRDEG LVNVSEPFTN LLTQGMVVAE TYYRDADGGK KQWINPADVE 600
VERDEKGRIV AAKLTADGAP VVIGGIEKMA KSKNNGVDPQ ALVDQYGADT 650
ARLFIIFAAP PDQQLEWSDS GVEGAYRFLR RVWSFGHAFV SEFRPQLPAD 700
RQLDAVQLPE ALAAVRREIH VCLRQANYDF GKHQFNTVVS AAMKILNALE 750
KAPRDVAAAH AQVAEEGLDI LLRLLAPITP HVAHALWQDC GFTGDVLHAS 800
WPEPSEDALR QDEIDLVLQV NGKLRGSLRV AAGASNSAIE ALALGSETAQ 850
KFMEGKPPRK VVVVPGRLVN IVV 873
Length:873
Mass (Da):97,432
Last modified:January 4, 2005 - v1
Checksum:i17317CB2086C0B1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI08612.1.
RefSeqiYP_159513.1. NC_006513.1.

Genome annotation databases

EnsemblBacteriaiCAI08612; CAI08612; ebA4386.
GeneIDi3182696.
KEGGieba:ebA4386.
PATRICi20971146. VBIAroAro98752_2516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR555306 Genomic DNA. Translation: CAI08612.1 .
RefSeqi YP_159513.1. NC_006513.1.

3D structure databases

ProteinModelPortali Q5P252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 76114.ebA4386.

Proteomic databases

PRIDEi Q5P252.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI08612 ; CAI08612 ; ebA4386 .
GeneIDi 3182696.
KEGGi eba:ebA4386.
PATRICi 20971146. VBIAroAro98752_2516.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AARO76114:GJTA-2513-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 2 hits.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1."
    Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.
    Arch. Microbiol. 183:27-36(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: EbN1.

Entry informationi

Entry nameiSYL_AROAE
AccessioniPrimary (citable) accession number: Q5P252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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